A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
An update to Hippocampome.org by integrating single-cell phenotypes with circuit function in vivo (2021)

Sanchez-Aguilera, A., Wheeler, D. W., Jurado-Parras, T., Valero, M., Nokia, M. S., Cid, E., Fernandez-Lamo, I., Sutton, N., García-Rincón, D., de la Prida, L. M., & Ascoli, G. A. (2021). An update to Hippocampome.org by integrating single-cell phenotypes with circuit function in vivo. PLoS Biology, 19(5), Article e3001213. https://doi.org/10.1371/journal.pbio.3001213

JYU-tekijät tai -toimittajat

Nokia, Miriam

Julkaisun tiedot

Julkaisun kaikki tekijät tai toimittajat: Sanchez-Aguilera, Alberto; Wheeler, Diek W.; Jurado-Parras, Teresa; Valero, Manuel; Nokia, Miriam S.; Cid, Elena; Fernandez-Lamo, Ivan; Sutton, Nate; García-Rincón, Daniel; de la Prida, Liset M.; et al.

Lehti tai sarja: PLoS Biology

ISSN: 1544-9173

eISSN: 1545-7885

Julkaisuvuosi: 2021

Ilmestymispäivä: 06.05.2021

Volyymi: 19

Lehden numero: 5

Artikkelinumero: e3001213

Kustantaja: Public Library of Science (PLoS)

Julkaisumaa: Yhdysvallat (USA)

Julkaisun kieli: englanti

DOI: https://doi.org/10.1371/journal.pbio.3001213

Julkaisun avoin saatavuus: Avoimesti saatavilla

Julkaisukanavan avoin saatavuus: Kokonaan avoin julkaisukanava

Julkaisu on rinnakkaistallennettu (JYX): https://jyx.jyu.fi/handle/123456789/75734

Tiivistelmä

Understanding brain operation demands linking basic behavioral traits to cell-type specific dynamics of different brain-wide subcircuits. This requires a system to classify the basic operational modes of neurons and circuits. Single-cell phenotyping of firing behavior during ongoing oscillations in vivo has provided a large body of evidence on entorhinal–hippocampal function, but data are dispersed and diverse. Here, we mined literature to search for information regarding the phase-timing dynamics of over 100 hippocampal/entorhinal neuron types defined in Hippocampome.org. We identified missing and unresolved pieces of knowledge (e.g., the preferred theta phase for a specific neuron type) and complemented the dataset with our own new data. By confronting the effect of brain state and recording methods, we highlight the equivalences and differences across conditions and offer a number of novel observations. We show how a heuristic approach based on oscillatory features of morphologically identified neurons can aid in classifying extracellular recordings of single cells and discuss future opportunities and challenges towards integrating single-cell phenotypes with circuit function.

YSO-asiasanat: hippokampus; hermosolut; fenotyyppi; hermoverkot (biologia); in vivo -menetelmä

Tieteenalat: