A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Relationship between inflammatory biomarkers and testosterone levels in male master athletes and non-athletes (2021)


Pinheiro Barbosa, L., da Silva Aguiar, S., Anderson Santos, P., Rosa dos Santos, T., Alves Maciel, L., Alves de Deus, L., Vanerson Passos Neves, R., Lopes de Araújo Leite, P., Duarte Gutierrez, S., Victor Sousa, C., Korhonen, M. T., Degens, H., & Gustavo Simões, H. (2021). Relationship between inflammatory biomarkers and testosterone levels in male master athletes and non-athletes. Experimental Gerontology, 151, Article 111407. https://doi.org/10.1016/j.exger.2021.111407


JYU-tekijät tai -toimittajat


Julkaisun tiedot

Julkaisun kaikki tekijät tai toimittajat: Pinheiro Barbosa, Luca ; da Silva Aguiar, Samuel; Anderson Santos, Patrick; Rosa dos Santos, Thiago; Alves Maciel, Larissa; Alves de Deus, Lysleine; Vanerson Passos Neves, Rodrigo; Lopes de Araújo Leite, Patrício; Duarte Gutierrez, Sara ; Victor Sousa, Caio; et al.

Lehti tai sarja: Experimental Gerontology

ISSN: 0531-5565

eISSN: 1873-6815

Julkaisuvuosi: 2021

Volyymi: 151

Artikkelinumero: 111407

Kustantaja: Elsevier

Julkaisumaa: Yhdysvallat (USA)

Julkaisun kieli: englanti

DOI: https://doi.org/10.1016/j.exger.2021.111407

Julkaisun avoin saatavuus: Ei avoin

Julkaisukanavan avoin saatavuus: Julkaisukanava ei ole avoin

Julkaisu on rinnakkaistallennettu (JYX): https://jyx.jyu.fi/handle/123456789/76503


Tiivistelmä

Background
Aging is often associated with low-grade systemic inflammation and reduced anabolic hormone levels. To investigate whether lifelong exercise training can decrease the age-related low-grade inflammation and anabolic hormone levels, we examined hormonal and inflammatory parameters among highly-trained male masters athletes and age-matched non-athletes.

Methods
From 70 elite power and endurance master athletes – EMA (51.3 ± 8.0 yr), 32 young controls - YC (23.7 ± 3.9 yr) and 24 untrained age-matched controls - MAC (47.2 ± 8.0 yr) venous blood was drawn to measure inflammatory parameters (interleukin-6 [IL-6], tumor necrosis factor-α [TNF-α] and interleukin-10 [IL-10]) and circulating hormones (luteinizing hormone [LH], total testosterone, estradiol, sex hormone-binding globulin [SHBG] and free androgen index [FAI]).

Results
EMA showed a better anti-inflammatory status than MAC (higher IL-10 and IL-10/IL-6 ratio and lower IL-6), but a lower anti-inflammatory status than YC (higher TNF-α) (p < 0.05). The MAC group had lower testosterone levels compared to the YC and EMA group (p < 0.05), and lower estradiol levels and testosterone/LH ratio compared to YC (p < 0.05). In the control groups (MAC and YC), testosterone correlated negatively with age and proinflammatory parameters, and positively with anti-inflammatory parameters.

Conclusion
Elite master athletics elevated levels of anti-inflammatory cytokines above that seen in non-athlete peers and mitigated the age-related reduction in testosterone levels.


YSO-asiasanat: ikääntyminen; keski-ikäiset; miehet; urheilijat; hormonaaliset vaikutukset; sukupuolihormonit; testosteroni; tulehdus; markkerit; hypogonadismi

Vapaat asiasanat: older athletes; hormonal profile; hypogonadism; master athletes; inflammation


Liittyvät organisaatiot


OKM-raportointi: Kyllä

Raportointivuosi: 2021

Alustava JUFO-taso: 1


Viimeisin päivitys 2021-20-09 klo 16:30