A1 Journal article (refereed)
Toxicological and bioactivity evaluation of blackcurrant press cake, sea buckthorn leaves and bark from Scots pine and Norway spruce extracts under a green integrated approach (2021)


Pap, N., Reshamwala, D., Korpinen, R., Kilpeläinen, P., Fidelis, M., Furtado, M. M., Sant’Ana, A. S., Wen, M., Zhang, L., Hellström, J., Marnilla, P., Mattila, P., Sarjala, T., Yang, B., dos Santos Lima, A., Azevedo, L., Marjomäki, V., & Granato, D. (2021). Toxicological and bioactivity evaluation of blackcurrant press cake, sea buckthorn leaves and bark from Scots pine and Norway spruce extracts under a green integrated approach. Food and Chemical Toxicology, 153, Article 112284. https://doi.org/10.1016/j.fct.2021.112284


JYU authors or editors


Publication details

All authors or editorsPap, Nora; Reshamwala, Dhanik; Korpinen, Risto; Kilpeläinen, Petri; Fidelis, Marina; Furtado, Marianna M.; Sant’Ana, Anderson S.; Wen, Mingchun; Zhang, Liang; Hellström, Jarkko; et al.

Journal or seriesFood and Chemical Toxicology

ISSN0278-6915

eISSN1873-6351

Publication year2021

Volume153

Article number112284

PublisherElsevier

Publication countryUnited Kingdom

Publication languageEnglish

DOIhttps://doi.org/10.1016/j.fct.2021.112284

Publication open accessOpenly available

Publication channel open accessPartially open access channel

Publication is parallel published (JYX)https://jyx.jyu.fi/handle/123456789/78579


Abstract

Aqueous extracts from blackcurrant press cake (BC), Norway spruce bark (NS), Scots pine bark (SP), and sea buckthorn leaves (SB) were obtained using maceration and pressurized hot water and tested for their bioactivities. Maceration provided the extraction of higher dry matter contents, including total phenolics (TPC), anthocyanins, and condensed tannins, which also impacted higher antioxidant activity. NS and SB extracts presented the highest mean values of TPC and antioxidant activity. Individually, NS extract presented high contents of proanthocyanidins, resveratrol, and some phenolic acids. In contrast, SB contained a high concentration of ellagitannins, ellagic acid, and quercetin, explaining the antioxidant activity and antibacterial effects. SP and BC extracts had the lowest TPC and antioxidant activity. However, BC had strong antiviral efficacy, whereas SP can be considered a potential ingredient to inhibit α-amylase. Except for BC, the other extracts decreased reactive oxygen species (ROS) generation in HCT8 and A549 cells. Extracts did not inhibit the production of TNF-alpha in lipopolysaccharide-stimulated THP-1 macrophages but inhibited the ROS generation during the THP-1 cell respiratory burst. The recovery of antioxidant compounds from these by-products is incentivized for high value-added applications.


Keywordsbioactive compoundsantimicrobial compoundstoxic substancesantioxidantsfree radicalsnaturally occurring substancesextraction (chemistry)circular economybiomass (industry)by-products

Free keywordsextraction technologies; bioactive compounds; circular economy; industrial by-products; natural resources; free radicals


Contributing organizations


Ministry reportingYes

VIRTA submission year2021

JUFO rating1


Last updated on 2024-22-04 at 20:57