A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Toxicological and bioactivity evaluation of blackcurrant press cake, sea buckthorn leaves and bark from Scots pine and Norway spruce extracts under a green integrated approach (2021)

Pap, N., Reshamwala, D., Korpinen, R., Kilpeläinen, P., Fidelis, M., Furtado, M. M., Sant’Ana, A. S., Wen, M., Zhang, L., Hellström, J., Marnilla, P., Mattila, P., Sarjala, T., Yang, B., dos Santos Lima, A., Azevedo, L., Marjomäki, V., & Granato, D. (2021). Toxicological and bioactivity evaluation of blackcurrant press cake, sea buckthorn leaves and bark from Scots pine and Norway spruce extracts under a green integrated approach. Food and Chemical Toxicology, 153, Article 112284. https://doi.org/10.1016/j.fct.2021.112284

JYU-tekijät tai -toimittajat

Julkaisun tiedot

Julkaisun kaikki tekijät tai toimittajat: Pap, Nora; Reshamwala, Dhanik; Korpinen, Risto; Kilpeläinen, Petri; Fidelis, Marina; Furtado, Marianna M.; Sant’Ana, Anderson S.; Wen, Mingchun; Zhang, Liang; Hellström, Jarkko; et al.

Lehti tai sarja: Food and Chemical Toxicology

ISSN: 0278-6915

eISSN: 1873-6351

Julkaisuvuosi: 2021

Volyymi: 153

Artikkelinumero: 112284

Kustantaja: Elsevier

Julkaisumaa: Britannia

Julkaisun kieli: englanti

DOI: https://doi.org/10.1016/j.fct.2021.112284

Julkaisun avoin saatavuus: Avoimesti saatavilla

Julkaisukanavan avoin saatavuus: Osittain avoin julkaisukanava

Julkaisu on rinnakkaistallennettu (JYX): https://jyx.jyu.fi/handle/123456789/78579

Tiivistelmä

Aqueous extracts from blackcurrant press cake (BC), Norway spruce bark (NS), Scots pine bark (SP), and sea buckthorn leaves (SB) were obtained using maceration and pressurized hot water and tested for their bioactivities. Maceration provided the extraction of higher dry matter contents, including total phenolics (TPC), anthocyanins, and condensed tannins, which also impacted higher antioxidant activity. NS and SB extracts presented the highest mean values of TPC and antioxidant activity. Individually, NS extract presented high contents of proanthocyanidins, resveratrol, and some phenolic acids. In contrast, SB contained a high concentration of ellagitannins, ellagic acid, and quercetin, explaining the antioxidant activity and antibacterial effects. SP and BC extracts had the lowest TPC and antioxidant activity. However, BC had strong antiviral efficacy, whereas SP can be considered a potential ingredient to inhibit α-amylase. Except for BC, the other extracts decreased reactive oxygen species (ROS) generation in HCT8 and A549 cells. Extracts did not inhibit the production of TNF-alpha in lipopolysaccharide-stimulated THP-1 macrophages but inhibited the ROS generation during the THP-1 cell respiratory burst. The recovery of antioxidant compounds from these by-products is incentivized for high value-added applications.

YSO-asiasanat: bioaktiiviset yhdisteet; antimikrobiset yhdisteet; myrkylliset aineet; antioksidantit; vapaat radikaalit; luonnonaineet; uutto; kiertotalous; biomassa (teollisuus); sivutuotteet

Vapaat asiasanat: extraction technologies; bioactive compounds; circular economy; industrial by-products; natural resources; free radicals

Liittyvät organisaatiot

OKM-raportointi: Kyllä

VIRTA-lähetysvuosi: 2021

JUFO-taso: 1