A1 Journal article (refereed)
Radiotherapy before or during androgen-deprivation therapy does not blunt the exercise-induced body composition protective effects in prostate cancer patients : A secondary analysis of two randomized controlled trials (2021)


Newton, R. U., Mavropalias, G., Fragala, M. S., Kraemer, W. J., Häkkinen, K., Taaffe, D. R., Spry, N., Joseph, D., & Galvão, D. A. (2021). Radiotherapy before or during androgen-deprivation therapy does not blunt the exercise-induced body composition protective effects in prostate cancer patients : A secondary analysis of two randomized controlled trials. Experimental Gerontology, 151, Article 111427. https://doi.org/10.1016/j.exger.2021.111427


JYU authors or editors


Publication details

All authors or editors: Newton, Robert U.; Mavropalias, Georgios; Fragala, Maren S.; Kraemer, William J.; Häkkinen, Keijo; Taaffe, Dennis R.; Spry, Nigel; Joseph, David; Galvão, Daniel A.

Journal or series: Experimental Gerontology

ISSN: 0531-5565

eISSN: 1873-6815

Publication year: 2021

Volume: 151

Article number: 111427

Publisher: Elsevier

Publication country: United States

Publication language: English

DOI: https://doi.org/10.1016/j.exger.2021.111427

Publication open access: Not open

Publication channel open access: Channel is not openly available

Publication is parallel published (JYX): https://jyx.jyu.fi/handle/123456789/76202


Abstract

Background
Androgen deprivation therapy (ADT) contributes to lean mass loss and adiposity increases in prostate cancer patients. Radiotherapy during ADT might act synergistically and further worsen body composition. Previous investigations have shown that resistance training is an effective method of preserving body composition during ADT, however, most have not accounted for direct or indirect effects of other therapies, such as radiotherapy. Therefore, the purpose of this study was to examine training adaptations of the tissue composition in patients receiving radiation therapy (RT) prior or during ADT.

Methods
Analyses were performed by combining data from two previous trials for a total of 131 prostate cancer patients who underwent a combination of resistance and aerobic exercise training (N = 70, age: 68.9 ± 6.6y, RT-before: 13%, RT-during: 14%) or usual care (N = 61, age: 67.5 ± 7.9y, RT-before: 16%, RT-during: 20%) for 3 months upon ADT onset. Whole-body lean mass (LM), fat percentage and appendicular LM were determined by dual energy x-ray absorptiometry, and lower-leg muscle area and density by peripheral computed tomography at baseline (onset of ADT) and at 3 months post-intervention. Covariates included RT prior and during the intervention, demographic characteristics, physical symptoms, and chronic conditions.

Results
Radiotherapy before or during the intervention did not affect body composition. Only the usual care group experienced a significant decrease in whole-body LM (−994 ± 150 g, P < 0.001) and appendicular LM (−126 ± 19 g, P < 0.001), and an increase in whole-body fat percentage (1% ± 0.1%, P < 0.001). There was no change in lower-leg muscle area or density in either group.

Conclusion
We suggest that radiation prior to and during ADT does not interfere with the beneficial effects of exercise training on body composition in men with prostate cancer.


Keywords: cancer treatments; radiotherapy; muscle mass; atrophy; muscular atrophies; body composition; exercise therapy; exercise (people)

Free keywords: muscle mass; hypertrophy; atrophy; adiposity; resistance exercise


Contributing organizations


Ministry reporting: Yes

Reporting Year: 2021

JUFO rating: 1


Last updated on 2022-12-08 at 10:03