A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Interactive effects of aging and aerobic capacity on energy metabolism–related metabolites of serum, skeletal muscle, and white adipose tissue (2021)

Zhuang, H., Karvinen, S., Törmäkangas, T., Zhang, X., Ojanen, X., Velagapudi, V., Alen, M., Britton, S. L., Koch, L. G., Kainulainen, H., Cheng, S., & Wiklund, P. (2021). Interactive effects of aging and aerobic capacity on energy metabolism–related metabolites of serum, skeletal muscle, and white adipose tissue. GeroScience, 43(6), 2679-2691. https://doi.org/10.1007/s11357-021-00387-1

JYU-tekijät tai -toimittajat

Zhuang, Haihui
Karvinen, Sira
Törmäkangas, Timo
Kainulainen, Heikki
Cheng, Shulin

Julkaisun tiedot

Julkaisun kaikki tekijät tai toimittajat: Zhuang, Haihui; Karvinen, Sira; Törmäkangas, Timo; Zhang, Xiaobo; Ojanen, Xiaowei; Velagapudi, Vidya; Alen, Markku; Britton, Steven L.; Koch, Lauren G.; Kainulainen, Heikki; et al.

Lehti tai sarja: GeroScience

ISSN: 2509-2715

eISSN: 2509-2723

Julkaisuvuosi: 2021

Ilmestymispäivä: 05.06.2021

Volyymi: 43

Lehden numero: 6

Artikkelin sivunumerot: 2679-2691

Kustantaja: Springer

Julkaisumaa: Sveitsi

Julkaisun kieli: englanti

DOI: https://doi.org/10.1007/s11357-021-00387-1

Julkaisun avoin saatavuus: Avoimesti saatavilla

Julkaisukanavan avoin saatavuus: Osittain avoin julkaisukanava

Julkaisu on rinnakkaistallennettu (JYX): https://jyx.jyu.fi/handle/123456789/76347

Tiivistelmä

Aerobic capacity is a strong predictor of longevity. With aging, aerobic capacity decreases concomitantly with changes in whole body metabolism leading to increased disease risk. To address the role of aerobic capacity, aging, and their interaction on metabolism, we utilized rat models selectively bred for low and high intrinsic aerobic capacity (LCRs/HCRs) and compared the metabolomics of serum, muscle, and white adipose tissue (WAT) at two time points: Young rats were sacrificed at 9 months of age, and old rats were sacrificed at 21 months of age. Targeted and semi-quantitative metabolomics analysis was performed on the ultra-pressure liquid chromatography tandem mass spectrometry (UPLC-MS) platform. The effects of aerobic capacity, aging, and their interaction were studied via regression analysis. Our results showed that high aerobic capacity is associated with an accumulation of isovalerylcarnitine in muscle and serum at rest, which is likely due to more efficient leucine catabolism in muscle. With aging, several amino acids were downregulated in muscle, indicating more efficient amino acid metabolism, whereas in WAT less efficient amino acid metabolism and decreased mitochondrial β-oxidation were observed. Our results further revealed that high aerobic capacity and aging interactively affect lipid metabolism in muscle and WAT, possibly combating unfavorable aging-related changes in whole body metabolism. Our results highlight the significant role of WAT metabolism for healthy aging.

YSO-asiasanat: aerobinen suorituskyky; ikääntyminen; aineenvaihdunta; rasva-aineenvaihdunta; aineenvaihduntatuotteet; koe-eläinmallit

Vapaat asiasanat: aerobic capacity; aging; metabolomics; metabolites

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