A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Stromal hyaluronan accumulation is associated with low immune response and poor prognosis in pancreatic cancer (2021)

Tahkola, K., Ahtiainen, M., Mecklin, J.-P., Kellokumpu, I., Laukkarinen, J., Tammi, M., Tammi, R., Väyrynen, J. P., & Böhm, J. (2021). Stromal hyaluronan accumulation is associated with low immune response and poor prognosis in pancreatic cancer. Scientific Reports, 11, Article 12216. https://doi.org/10.1038/s41598-021-91796-x

JYU-tekijät tai -toimittajat

Julkaisun tiedot

Julkaisun kaikki tekijät tai toimittajat: Tahkola, Kyösti; Ahtiainen, Maarit; Mecklin, Jukka-Pekka; Kellokumpu, Ilmo; Laukkarinen, Johanna; Tammi, Markku; Tammi, Raija; Väyrynen, Juha P.; Böhm, Jan

Lehti tai sarja: Scientific Reports

eISSN: 2045-2322

Julkaisuvuosi: 2021

Ilmestymispäivä: 09.06.2021

Volyymi: 11

Artikkelinumero: 12216

Kustantaja: Nature Publishing Group

Julkaisumaa: Britannia

Julkaisun kieli: englanti

DOI: https://doi.org/10.1038/s41598-021-91796-x

Julkaisun avoin saatavuus: Avoimesti saatavilla

Julkaisukanavan avoin saatavuus: Kokonaan avoin julkaisukanava

Julkaisu on rinnakkaistallennettu (JYX): https://jyx.jyu.fi/handle/123456789/76647

Tiivistelmä

Hyaluronan (HA) accumulation has been associated with poor survival in various cancers, but the mechanisms for this phenomenon are still unclear. The aim of this study was to investigate the prognostic significance of stromal HA accumulation and its association with host immune response in pancreatic ductal adenocarcinoma (PDAC). The study material consisted of 101 radically treated patients for PDAC from a single geographical area. HA staining was evaluated using a HA-specific probe, and the patterns of CD3, CD8, CD73 and PD-L1 expression were evaluated using immunohistochemistry. HA staining intensity of tumour stromal areas was assessed digitally using QuPath. CD3- and CD8-based immune cell score (ICS) was determined. High-level stromal HA expression was significantly associated with poor disease-specific survival (p = 0.037) and overall survival (p = 0.013) In multivariate analysis, high-level stromal HA expression was an independent negative prognostic factor together with histopathological grade, TNM stage, CD73 positivity in tumour cells and low ICS. Moreover, high-level stromal HA expression was associated with low ICS (p = 0.017). In conclusion, stromal HA accumulation is associated with poor survival and low immune response in PDAC.

YSO-asiasanat: syöpätaudit; haimasyöpä; ennusteet; immuunivaste; biomarkkerit; hyaluronaani

Liittyvät organisaatiot

OKM-raportointi: Kyllä

VIRTA-lähetysvuosi: 2021

JUFO-taso: 1