A1 Journal article (refereed)
Long-term health-related quality of life of breast cancer survivors remains impaired compared to the age-matched general population especially in young women : Results from the prospective controlled BREX exercise study (2021)
Roine, E., Sintonen, H., Kellokumpu-Lehtinen, P.-L., Penttinen, H., Utriainen, M., Vehmanen, L., Huovinen, R., Kautiainen, H., Nikander, R., Blomqvist, C., Hakamies-Blomqvist, L., & Saarto, T. (2021). Long-term health-related quality of life of breast cancer survivors remains impaired compared to the age-matched general population especially in young women : Results from the prospective controlled BREX exercise study. Breast, 59, 110-116. https://doi.org/10.1016/j.breast.2021.06.012
JYU authors or editors
Publication details
All authors or editors: Roine, Eija; Sintonen, Harri; Kellokumpu-Lehtinen, Pirkko-Liisa; Penttinen, Heidi; Utriainen, Meri; Vehmanen, Leena; Huovinen, Riikka; Kautiainen, Hannu; Nikander, Riku; Blomqvist, Carl; et al.
Journal or series: Breast
ISSN: 0960-9776
eISSN: 1532-3080
Publication year: 2021
Volume: 59
Pages range: 110-116
Publisher: Elsevier
Publication country: Netherlands
Publication language: English
DOI: https://doi.org/10.1016/j.breast.2021.06.012
Publication open access: Openly available
Publication channel open access: Partially open access channel
Publication is parallel published (JYX): https://jyx.jyu.fi/handle/123456789/77015
Abstract
To investigate long-term health-related quality of life (HRQoL) changes over time in younger compared to older disease-free breast cancer survivors who participated in a prospective randomized exercise trial.
Methods
Survivors (aged 35–68 years) were randomized to a 12-month exercise trial after adjuvant treatment and followed up for ten years. HRQoL was assessed with the generic 15D instrument during follow-up and the younger (baseline age ≤ 50) and older (age >50) survivors’ HRQoL was compared to that of the age-matched general female population (n = 892). The analysis included 342 survivors.
Results
The decline of HRQoL compared to the population was steeper and recovery slower in the younger survivors (p for interaction < 0.001). The impairment was also larger among the younger survivors (p = 0.027) whose mean HRQoL deteriorated for three years after treatment and started to slowly improve thereafter but still remained below the population level after ten years (difference −0.017, 95% CI: 0.031 to −0.004). The older survivors’ mean HRQoL gradually approached the population level during the first five years but also remained below it at ten years (difference −0.019, 95% CI: 0.032 to −0.007). The largest differences were on the dimensions of sleeping and sexual activity, on which both age groups remained below the population level throughout the follow-up.
Conclusions
HRQoL developed differently in younger and older survivors both regarding the most affected dimensions of HRQoL and the timing of the changes during follow-up. HRQoL of both age groups remained below the population level even ten years after treatment.
Keywords: cancerous diseases; breast cancer; return to health; quality of life; exercise (people); exercise therapy; follow-up study
Free keywords: breast neoplasms; cancer survivors; exercise; follow-up studies; health-related quality of life; utility
Contributing organizations
Ministry reporting: Yes
Reporting Year: 2021
JUFO rating: 1
