A1 Journal article (refereed)
Long-term health-related quality of life of breast cancer survivors remains impaired compared to the age-matched general population especially in young women : Results from the prospective controlled BREX exercise study (2021)


Roine, E., Sintonen, H., Kellokumpu-Lehtinen, P.-L., Penttinen, H., Utriainen, M., Vehmanen, L., Huovinen, R., Kautiainen, H., Nikander, R., Blomqvist, C., Hakamies-Blomqvist, L., & Saarto, T. (2021). Long-term health-related quality of life of breast cancer survivors remains impaired compared to the age-matched general population especially in young women : Results from the prospective controlled BREX exercise study. Breast, 59, 110-116. https://doi.org/10.1016/j.breast.2021.06.012


JYU authors or editors


Publication details

All authors or editors: Roine, Eija; Sintonen, Harri; Kellokumpu-Lehtinen, Pirkko-Liisa; Penttinen, Heidi; Utriainen, Meri; Vehmanen, Leena; Huovinen, Riikka; Kautiainen, Hannu; Nikander, Riku; Blomqvist, Carl; et al.

Journal or series: Breast

ISSN: 0960-9776

eISSN: 1532-3080

Publication year: 2021

Volume: 59

Pages range: 110-116

Publisher: Elsevier

Publication country: Netherlands

Publication language: English

DOI: https://doi.org/10.1016/j.breast.2021.06.012

Publication open access: Openly available

Publication channel open access: Partially open access channel

Publication is parallel published (JYX): https://jyx.jyu.fi/handle/123456789/77015


Abstract

Objective
To investigate long-term health-related quality of life (HRQoL) changes over time in younger compared to older disease-free breast cancer survivors who participated in a prospective randomized exercise trial.

Methods
Survivors (aged 35–68 years) were randomized to a 12-month exercise trial after adjuvant treatment and followed up for ten years. HRQoL was assessed with the generic 15D instrument during follow-up and the younger (baseline age ≤ 50) and older (age >50) survivors’ HRQoL was compared to that of the age-matched general female population (n = 892). The analysis included 342 survivors.

Results
The decline of HRQoL compared to the population was steeper and recovery slower in the younger survivors (p for interaction < 0.001). The impairment was also larger among the younger survivors (p = 0.027) whose mean HRQoL deteriorated for three years after treatment and started to slowly improve thereafter but still remained below the population level after ten years (difference −0.017, 95% CI: 0.031 to −0.004). The older survivors’ mean HRQoL gradually approached the population level during the first five years but also remained below it at ten years (difference −0.019, 95% CI: 0.032 to −0.007). The largest differences were on the dimensions of sleeping and sexual activity, on which both age groups remained below the population level throughout the follow-up.

Conclusions
HRQoL developed differently in younger and older survivors both regarding the most affected dimensions of HRQoL and the timing of the changes during follow-up. HRQoL of both age groups remained below the population level even ten years after treatment.


Keywords: cancerous diseases; breast cancer; return to health; quality of life; exercise (people); exercise therapy; follow-up study

Free keywords: breast neoplasms; cancer survivors; exercise; follow-up studies; health-related quality of life; utility


Contributing organizations


Ministry reporting: Yes

Preliminary JUFO rating: 1


Last updated on 2021-06-07 at 12:14