A1 Journal article (refereed)
Effect of 12-month supervised, home-based physical exercise on functioning among persons with signs of frailty : Randomized Controlled Trial (2021)

Suikkanen, S., Soukkio, P., Aartolahti, E., Kääriä, S., Kautiainen, H., Hupli, M. T., Pitkälä, K., Sipilä, S., & Kukkonen-Harjula, K. (2021). Effect of 12-month supervised, home-based physical exercise on functioning among persons with signs of frailty : Randomized Controlled Trial. Archives of Physical Medicine and Rehabilitation, 102(12), 2283-2290. https://doi.org/10.1016/j.apmr.2021.06.017

JYU authors or editors

Publication details

All authors or editors: Suikkanen, Sara; Soukkio, Paula; Aartolahti, Eeva; Kääriä, Sanna; Kautiainen, Hannu; Hupli, Markku T.; Pitkälä, Kaisu; Sipilä, Sarianna; Kukkonen-Harjula, Katriina

Journal or series: Archives of Physical Medicine and Rehabilitation

ISSN: 0003-9993

eISSN: 1532-821X

Publication year: 2021

Volume: 102

Issue number: 12

Pages range: 2283-2290

Publisher: Elsevier BV

Publication country: United States

Publication language: English

DOI: https://doi.org/10.1016/j.apmr.2021.06.017

Publication open access: Not open

Publication channel open access:

Publication is parallel published (JYX): https://jyx.jyu.fi/handle/123456789/78895


To investigate the effects of a 12-month home-based exercise program on functioning and falls among persons with signs of frailty.

A randomized controlled trial with a 1:1 allocation


Home-dwelling persons aged ≥65 years meeting at least one frailty phenotype criteria (n=300).

12-month, individually tailored, progressive and physiotherapist-supervised, physical exercise twice a week (n=150) vs. usual care (n=149).

Main outcome Measures
Functional Independence Measure (FIM), Short Physical Performance Battery (SPPB), handgrip strength, instrumental activities of daily living (IADL), and self-reported falls and physical activity (other than intervention). Assessed four times at home over 12 months.

The mean age of the participants was 82.2 (SD 6.3), 75% were women, 61% met 1–2 frailty criteria and 39% ≥3 criteria. FIM deteriorated in both groups over 12 months, -4.1 points (95% CI: -5.6 to -2.5) in the exercise group and -6.9 (-8.4 to -2.3) in the usual care group (group p=0.014, time p<0.001, interaction p=0.56). The mean improvement in SPPB was significantly greater in the exercise group [1.6 (1.3 to 2.0)] than in the usual care group [0.01 (-0.3 to 0.3)] (group p<0.001, time p=0.11, interaction p=0.027). The exercise group reported significantly fewer falls per person-year compared to the usual care group (incidence rate ratio, IRR 0.47 [95% CI 0.40 to 0.55]; p<0.001). There was no significant difference between the groups over 12 months in terms of handgrip strength, IADL function or self-reported physical activity.

One year of physical exercise improved physical performance and decreased the number of falls among people with signs of frailty. FIM differed between the groups at 12 months, but exercise did not prevent deterioration of FIM, IADL or handgrip strength.

Keywords: ageing; physical activeness; physical fitness; physical training; physiotherapy; performance (physical capacity); functional capacity

Free keywords: physical therapy; physical functional performance; functional status; aging

Contributing organizations

Ministry reporting: Yes

Preliminary JUFO rating: 3

Last updated on 2021-07-12 at 11:42