A1 Journal article (refereed)
The Impact of Nordic Walking on Bone Properties in Postmenopausal Women with Pre-Diabetes and Non-Alcohol Fatty Liver Disease (2021)

Du, X., Zhang, C., Zhang, X., Qi, Z., Cheng, S., & Le, S. (2021). The Impact of Nordic Walking on Bone Properties in Postmenopausal Women with Pre-Diabetes and Non-Alcohol Fatty Liver Disease. International Journal of Environmental Research and Public Health, 18(14), Article 7570. https://doi.org/10.3390/ijerph18147570

JYU authors or editors

Publication details

All authors or editors: Du, Xiaming; Zhang, Chao; Zhang, Xiangqi; Qi, Zhen; Cheng, Sulin; Le, Shenglong

Journal or series: International Journal of Environmental Research and Public Health

ISSN: 1661-7827

eISSN: 1660-4601

Publication year: 2021

Publication date: 16/07/2021

Volume: 18

Issue number: 14

Article number: 7570

Publisher: MDPI AG

Publication country: Switzerland

Publication language: English

DOI: https://doi.org/10.3390/ijerph18147570

Publication open access: Openly available

Publication channel open access: Open Access channel

Publication is parallel published (JYX): https://jyx.jyu.fi/handle/123456789/77396

Abstract

This study investigated the impact of Nordic walking on bone properties in postmenopausal women with pre-diabetes and non-alcohol fatty liver disease (NAFLD). A total of 63 eligible women randomly participated in the Nordic walking training (AEx, n = 33), or maintained their daily lifestyle (Con, n = 30) during intervention. Bone mineral content (BMC) and density (BMD) of whole body (WB), total femur (TF), femoral neck (FN), and lumbar spine (L2-4) were assessed by dual-energy X-ray absorptiometry. Serum osteocalcin, pentosidine, receptor activator of nuclear factor kappa-B ligand (RANKL) levels were analyzed by ELISA assay. After an 8.6-month intervention, the AEx group maintained their BMCTF, BMDTF, BMCL2−4, and BMDL2−4, and increased their BMCFN (p = 0.016), while the Con group decreased their BMCTF (p = 0.008), BMDTF (p = 0.001), and BMDL2−4 (p = 0.002). However, no significant group × time interaction was observed, except for BMDL2−4 (p = 0.013). Decreased pentosidine was correlated with increased BMCWB(r = −0.352, p = 0.019). The intervention has no significant effect on osteocalcin and RANKL. Changing of bone mass was associated with changing of pentosidine, but not with osteocalcin and RANKL. Our results suggest that Nordic walking is effective in preventing bone loss among postmenopausal women with pre-diabetes and NAFLD.

Keywords: older people; women; non-alcoholic fatty liver disease; adult-onset diabetes; exercise (people); nordic walking; bone density; biomarkers

Free keywords: Nordic walking; postmenopausal women; fatty liver disease; bone markers; bone mineral density

Contributing organizations

Ministry reporting: Yes

Reporting Year: 2021

JUFO rating: 1