A1 Journal article (refereed)
Ion mobility mass spectrometry : an efficient tool for the analysis of conformational switch of macrocyclic receptors upon anion binding (2021)
Zimnicka, M., Kalenius, E., Jurczak, J., & Danikiewicz, W. (2021). Ion mobility mass spectrometry : an efficient tool for the analysis of conformational switch of macrocyclic receptors upon anion binding. Analyst, 146(17), 5337-5346. https://doi.org/10.1039/D1AN00958C
JYU authors or editors
Publication details
All authors or editors: Zimnicka, Magdalena; Kalenius, Elina; Jurczak, Janusz; Danikiewicz, Witold
Journal or series: Analyst
ISSN: 0003-2654
eISSN: 1364-5528
Publication year: 2021
Volume: 146
Issue number: 17
Pages range: 5337-5346
Publisher: Royal Society of Chemistry (RSC)
Publication country: United Kingdom
Publication language: English
DOI: https://doi.org/10.1039/D1AN00958C
Publication open access: Not open
Publication channel open access:
Abstract
Interactions between anions and synthetic macrocyclic receptors belong to the extensively explored area of research due to the particularly important functions of anions in biological and environmental sciences. Structures of anion-macrocycle complexes are closely related to their function, highlighting the importance of structural analysis of the complexes. Here, we discuss the application of ion mobility mass spectrometry (IM-MS) and theoretical calculations to the structural analysis of tetralactam macrocycles (M) with varying flexibility and structural properties, and their complexes with anions [M + X]−. Collision cross section (CCS) values obtained from both direct drift tube (DT) and indirect using traveling-wave (TW) IM-MS measurements supplemented by theoretical calculations were successfully used to describe the structural properties of various macrocycle-anion complexes, proving the suitability of the IM-MS approach for sensitive, selective, and fast detection of anion complexes and characterization of their structures and conformations.
Keywords: anions; chemical bonds; coordination complexes; mass spectrometry
Contributing organizations
Ministry reporting: Yes
Reporting Year: 2021
JUFO rating: 1
