A2 Review article, Literature review, Systematic review
Concepts to Reveal Parvovirus–Nucleus Interactions (2021)

Mattola, S., Hakanen, S., Salminen, S., Aho, V., Mäntylä, E., Ihalainen, T. O., Kann, M., & Vihinen-Ranta, M. (2021). Concepts to Reveal Parvovirus–Nucleus Interactions. Viruses, 13(7), Article 1306. https://doi.org/10.3390/v13071306

JYU authors or editors

Mattola, Salla
Hakanen, Satu
Salminen, Sami
Aho, Vesa
Vihinen-Ranta, Maija

Publication details

All authors or editors: Mattola, Salla; Hakanen, Satu; Salminen, Sami; Aho, Vesa; Mäntylä, Elina; Ihalainen, Teemu O.; Kann, Michael; Vihinen-Ranta, Maija

Journal or series: Viruses

eISSN: 1999-4915

Publication year: 2021

Publication date: 05/07/2021

Volume: 13

Issue number: 7

Article number: 1306

Publisher: MDPI AG

Publication country: Switzerland

Publication language: English

DOI: https://doi.org/10.3390/v13071306

Publication open access: Openly available

Publication channel open access: Open Access channel

Publication is parallel published (JYX): https://jyx.jyu.fi/handle/123456789/77403

Abstract

Parvoviruses are small single-stranded (ss) DNA viruses, which replicate in the nucleoplasm and affect both the structure and function of the nucleus. The nuclear stage of the parvovirus life cycle starts at the nuclear entry of incoming capsids and culminates in the successful passage of progeny capsids out of the nucleus. In this review, we will present past, current, and future microscopy and biochemical techniques and demonstrate their potential in revealing the dynamics and molecular interactions in the intranuclear processes of parvovirus infection. In particular, a number of advanced techniques will be presented for the detection of infection-induced changes, such as DNA modification and damage, as well as protein–chromatin interactions.

Keywords: viruses; parvoviruses; infections; cell nucleus; proteins; imaging; microscopy

Free keywords: parvoviruses; nucleus; imaging of viral interactions and dynamics; analysis of protein–protein interactions; analysis of virus–chromatin interactions

Fields of science: