Liver fat biomarkers study from the 'Personalized diet intervention to treat fatty liver' project


Anastasiia Driuchina; Jukka Hintikka; Marko Lehtonen; Pekka Keski-Rahkonen; Thomas O’Connell; Risto Juvonen; Juho Kuula; Antti Hakkarainen; Jari A. Laukkanen; Elina Mäkinen; Sanna Lensu et al. (2023). Liver fat biomarkers study from the 'Personalized diet intervention to treat fatty liver' project. https://doi.org/10.17011/jyx/dataset/85068.


JYU authors:
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  • Contact person (yes/no): No
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All authors: Anastasiia Driuchina; Jukka Hintikka; Marko Lehtonen; Pekka Keski-Rahkonen; Thomas O’Connell; Risto Juvonen; Juho Kuula; Antti Hakkarainen; Jari A. Laukkanen; Elina Mäkinen; Sanna Lensu; Kirsi H. Pietiläinen; Satu Pekkala

Funders: Academy of Finland; Finnish Cultural Foundation

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Availability and identifiers

Availability: Contact owner

Publication year: 2023

URN identifier in JYX: http://urn.fi/URN:NBN:fi:jyu-202301181370

DOI identifier in JYX: https://doi.org/10.17011/jyx/dataset/85068


Description of the dataset

Description: The study aimed at finding gut microbiota signatures and metabolite markers in plasma and feces related to high liver fat content in humans. Based on imaging, we divided study participants into low (<5%, LF, n=25) and high (>5%, HF, n=39) liver fat groups. Fecal (LF n=14, HF n=25) and plasma (LF n=11, HF n=7) metabolomes of subsets of participants were studied using liquid chromatography/high resolution mass spectrometry. The gut microbiota were analyzed using 16S rRNA gene sequencing. Additionally, blood clinical variables, body composition and diet were studied.

The list of metadata variables can be found below. They are categorized by the type of sample and/or analysis.

BLOOD CLINICAL VARIABLES & UNITS

alanine aminotransferase, ALT (U/L)
aspartate aminotransferase, AST (U/L)
gamma-glutamyltransferase, GGT(U/L)
total cholesterol (mmol/L)
high-density lipoprotein, HDL (mmol/L)
low-density lipoprotein, LDL (mmol/L)
triglycrides (mmol/L)
glucose (mmol/L)
insulin (iU/L)
HOMA-IR


BODY COMPOSITION VARIABLES & UNITS

Height (cm)
Weight (kg)
body mass index, BMI (kg/m2)
Waist circumference (cm)
blood pressure (BP) systolic (mm Hg)
blood pressure (BP) diastolic (mm Hg)
Liver fat %


GUT MICROBIOTA COMPOSITION

fastq files of the sequences
OUT counts per each sample
relative abundance per each sample
diversity measures (Shannon, Chao1, phylogenetic diversity, Bray Curtis distance)


METABOLITES

plasma metabolites & identification information
fecal metabolites & identification information


DIETARY INTAKES & UNITS (from 3 different days & average from 3 days)

Energy (kJ)
Energy (kcal)
Protein (g)
Carbohydrates (g)
Fat (g)
Alcohol
Coffee (dl/3 days) *
Fatty acids (g)
Monosaturated Fatty acids (g)
Polyunsaturated Fatty acids (g)
Sucrose (g)
Fiber, total (g)
Vitamin C (mg)
Thiamine (B1) (mg)
Vitamin E (mg)
Vitamin A (µg)
Vitamin D (µg)
Riboflavin (B2) (mg)
Vitamin K (mg)
Vitamin B6 (mg)
Folate (B9) (µg)
Sodium (mg)
Magnesium (mg)
Calcium (mg)
Potassium (mg)
Iron (mg)
Iodine (µg)
Phosphorus (mg)
Selenium (µg)
Zinc (mg)
Fatty acids, total (g)
Cholesterol (mg)
Fatty acids, trans (g)
Lactose (g)
Fiber, total amount (g)
Vitamin B12 (cobalamine) (µg)
Salt (mg)
Omega-6 Fatty acids (g)
Omega-3 Fatty acids (g).

Language: English

Free keywords: liver fat; gut microbiota; metabolites; biomarkers; clinical biochemistry; liver enzymes; body composition

Keywords (YSO): fatty liver; microbiology; insulin resistance; metabolism

Fields of science: 319 Other medical sciences

Do you deal with data concerning special categories of personal data in your research?: Yes


Projects related to dataset


Last updated on 2023-18-01 at 15:17