Liver fat biomarkers study from the 'Personalized diet intervention to treat fatty liver' project


Pekkala, Satu; Hintikka, Jukka; Mäkinen, Elina; Lensu, Sanna; Lehtonen, Marko; Keski-Rahkonen, Pekka; O'Connell, Thomas; Juvonen, Risto; Kuula, Juho; Hakkarainen, Antti; Laukkanen, Jari et al. (2023). Liver fat biomarkers study from the 'Personalized diet intervention to treat fatty liver' project. University of Jyväskylä. https://doi.org/10.17011/jyx/dataset/85068.


JYU authors
  • Contact person (yes/no)Yes
  • Contact person (yes/no)No
  • Contact person (yes/no)No
  • Contact person (yes/no)No

All authorsPekkala, Satu; Hintikka, Jukka; Mäkinen, Elina; Lensu, Sanna; Lehtonen, Marko; Keski-Rahkonen, Pekka; O'Connell, Thomas; Juvonen, Risto; Kuula, Juho; Hakkarainen, Antti; Laukkanen, Jari; Pietiläinen, Kirsi

FundersResearch Council of FinlandFinnish Cultural Foundation

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Contributors


Availability and identifiers

AvailabilityContact owner

Publication year2023

URN identifier in original repositoryhttp://urn.fi/URN:NBN:fi:jyu-202301181370

DOI identifier in original repositoryhttps://doi.org/10.17011/jyx/dataset/85068

URN identifier in JYXhttp://urn.fi/URN:NBN:fi:jyu-202301181370

DOI identifier in JYXhttps://doi.org/10.17011/jyx/dataset/85068


Description of the dataset

DescriptionThe study aimed at finding gut microbiota signatures and metabolite markers in plasma and feces related to high liver fat content in humans. Based on imaging, we divided study participants into low (<5%, LF, n=25) and high (>5%, HF, n=39) liver fat groups. Fecal (LF n=14, HF n=25) and plasma (LF n=11, HF n=7) metabolomes of subsets of participants were studied using liquid chromatography/high resolution mass spectrometry. The gut microbiota were analyzed using 16S rRNA gene sequencing. Additionally, blood clinical variables, body composition and diet were studied.

The list of metadata variables can be found below. They are categorized by the type of sample and/or analysis.

BLOOD CLINICAL VARIABLES & UNITS

alanine aminotransferase, ALT (U/L)
aspartate aminotransferase, AST (U/L)
gamma-glutamyltransferase, GGT(U/L)
total cholesterol (mmol/L)
high-density lipoprotein, HDL (mmol/L)
low-density lipoprotein, LDL (mmol/L)
triglycrides (mmol/L)
glucose (mmol/L)
insulin (iU/L)
HOMA-IR


BODY COMPOSITION VARIABLES & UNITS

Height (cm)
Weight (kg)
body mass index, BMI (kg/m2)
Waist circumference (cm)
blood pressure (BP) systolic (mm Hg)
blood pressure (BP) diastolic (mm Hg)
Liver fat %


GUT MICROBIOTA COMPOSITION

fastq files of the sequences
OUT counts per each sample
relative abundance per each sample
diversity measures (Shannon, Chao1, phylogenetic diversity, Bray Curtis distance)


METABOLITES

plasma metabolites & identification information
fecal metabolites & identification information


DIETARY INTAKES & UNITS (from 3 different days & average from 3 days)

Energy (kJ)
Energy (kcal)
Protein (g)
Carbohydrates (g)
Fat (g)
Alcohol
Coffee (dl/3 days) *
Fatty acids (g)
Monosaturated Fatty acids (g)
Polyunsaturated Fatty acids (g)
Sucrose (g)
Fiber, total (g)
Vitamin C (mg)
Thiamine (B1) (mg)
Vitamin E (mg)
Vitamin A (µg)
Vitamin D (µg)
Riboflavin (B2) (mg)
Vitamin K (mg)
Vitamin B6 (mg)
Folate (B9) (µg)
Sodium (mg)
Magnesium (mg)
Calcium (mg)
Potassium (mg)
Iron (mg)
Iodine (µg)
Phosphorus (mg)
Selenium (µg)
Zinc (mg)
Fatty acids, total (g)
Cholesterol (mg)
Fatty acids, trans (g)
Lactose (g)
Fiber, total amount (g)
Vitamin B12 (cobalamine) (µg)
Salt (mg)
Omega-6 Fatty acids (g)
Omega-3 Fatty acids (g).

LanguageEnglish

Free keywordsliver fat; gut microbiota; metabolites; biomarkers; clinical biochemistry; liver enzymes; body composition

Keywords (YSO)fatty livermicrobiologyinsulin resistancemetabolism

Fields of science319 Other medical sciences

Do you deal with data concerning special categories of personal data in your research?Yes


Projects related to dataset


Last updated on 2023-07-08 at 10:58