A1 Journal article (refereed)
Total and regional body adiposity increases during menopause : evidence from a follow‐up study (2022)
Juppi, H., Sipilä, S., Fachada, V., Hyvärinen, M., Cronin, N., Aukee, P., Karppinen, J. E., Selänne, H., Kujala, U. M., Kovanen, V., Karvinen, S., & Laakkonen, E. K. (2022). Total and regional body adiposity increases during menopause : evidence from a follow‐up study. Aging Cell, 21(6), Article e13621. https://doi.org/10.1111/acel.13621
JYU authors or editors
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Publication details
All authors or editors: Juppi, Hanna‐Kaarina; Sipilä, Sarianna; Fachada, Vasco; Hyvärinen, Matti; Cronin, Neil; Aukee, Pauliina; Karppinen, Jari E.; Selänne, Harri; Kujala, Urho M.; Kovanen, Vuokko; et al.
Journal or series: Aging Cell
ISSN: 1474-9718
eISSN: 1474-9726
Publication year: 2022
Publication date: 04/05/2022
Volume: 21
Issue number: 6
Article number: e13621
Publisher: Wiley-Blackwell
Publication country: United Kingdom
Publication language: English
DOI: https://doi.org/10.1111/acel.13621
Publication open access: Openly available
Publication channel open access: Open Access channel
Publication is parallel published (JYX): https://jyx.jyu.fi/handle/123456789/81116
Abstract
For women, menopausal transition is a time of significant hormonal changes, which may contribute to altered body composition and regional adipose tissue accumulation. Excess adiposity, and especially adipose tissue accumulation in the central body region, increases women's risk of cardiovascular and metabolic conditions and affects physical functioning. We investigated the associations between menopausal progression and total and regional body adiposity measured with dual-energy X-ray absorptiometry and computed tomography in two longitudinal cohort studies of women aged 47–55 (n = 230 and 148, mean follow-up times 1.3 ± 0.7 and 3.9 ± 0.2 years, mean baseline BMI 25.5 kg/m2). We also examined associations between menopausal progression and skeletal muscle fiber characteristics, as well as adipose tissue-derived adipokines. Relative increases of 2%–14% were observed in regional and total body adiposity measures, with a pronounced fat mass increase in the android area (4% and 14% during short- and long-term follow-ups). Muscle fiber oxidative and glycolytic capacities and intracellular adiposity were not affected by menopause, but were differentially correlated with total and regional body adiposity at different menopausal stages. Menopausal progression and regional adipose tissue masses were positively associated with serum adiponectin and leptin, and negatively associated with resistin levels. Higher diet quality and physical activity level were also inversely associated with several body adiposity measures. Therefore, healthy lifestyle habits before and during menopause might delay the onset of severe metabolic conditions in women.
Keywords: women; body composition; adipose tissues; muscles; obesity; ageing; menopause; physical activity; longitudinal research; follow-up study
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Related research datasets
Ministry reporting: Yes
VIRTA submission year: 2022
JUFO rating: 2
- Gerontology and Public Health (Faculty of Sport and Health Sciences LTK, SPORT) TGE
- Gerontology Research Center (Faculty of Sport and Health Sciences LTK, SPORT) GEREC
- Exercise Physiology (Faculty of Sport and Health Sciences LTK, SPORT) LFY
- Biomechanics (Faculty of Sport and Health Sciences LTK, SPORT) BME
- Sports and Exercise Medicine (Faculty of Sport and Health Sciences LTK, SPORT) LLT
- School of Wellbeing (University of Jyväskylä JYU) JYU.Well