A1 Journal article (refereed)
Total and regional body adiposity increases during menopause : evidence from a follow‐up study (2022)

Juppi, H., Sipilä, S., Fachada, V., Hyvärinen, M., Cronin, N., Aukee, P., Karppinen, J. E., Selänne, H., Kujala, U. M., Kovanen, V., Karvinen, S., & Laakkonen, E. K. (2022). Total and regional body adiposity increases during menopause : evidence from a follow‐up study. Aging Cell, 21(6), Article e13621. https://doi.org/10.1111/acel.13621

JYU authors or editors

Publication details

All authors or editorsJuppi, Hanna‐Kaarina; Sipilä, Sarianna; Fachada, Vasco; Hyvärinen, Matti; Cronin, Neil; Aukee, Pauliina; Karppinen, Jari E.; Selänne, Harri; Kujala, Urho M.; Kovanen, Vuokko; et al.

Journal or seriesAging Cell



Publication year2022

Publication date04/05/2022


Issue number6

Article numbere13621


Publication countryUnited Kingdom

Publication languageEnglish


Publication open accessOpenly available

Publication channel open accessOpen Access channel

Publication is parallel published (JYX)https://jyx.jyu.fi/handle/123456789/81116


For women, menopausal transition is a time of significant hormonal changes, which may contribute to altered body composition and regional adipose tissue accumulation. Excess adiposity, and especially adipose tissue accumulation in the central body region, increases women's risk of cardiovascular and metabolic conditions and affects physical functioning. We investigated the associations between menopausal progression and total and regional body adiposity measured with dual-energy X-ray absorptiometry and computed tomography in two longitudinal cohort studies of women aged 47–55 (n = 230 and 148, mean follow-up times 1.3 ± 0.7 and 3.9 ± 0.2 years, mean baseline BMI 25.5 kg/m2). We also examined associations between menopausal progression and skeletal muscle fiber characteristics, as well as adipose tissue-derived adipokines. Relative increases of 2%–14% were observed in regional and total body adiposity measures, with a pronounced fat mass increase in the android area (4% and 14% during short- and long-term follow-ups). Muscle fiber oxidative and glycolytic capacities and intracellular adiposity were not affected by menopause, but were differentially correlated with total and regional body adiposity at different menopausal stages. Menopausal progression and regional adipose tissue masses were positively associated with serum adiponectin and leptin, and negatively associated with resistin levels. Higher diet quality and physical activity level were also inversely associated with several body adiposity measures. Therefore, healthy lifestyle habits before and during menopause might delay the onset of severe metabolic conditions in women.

Keywordswomenbody compositionadipose tissuesmusclesobesityageingmenopausephysical activitylongitudinal researchfollow-up study

Free keywordsadipokine; body fat distribution; longitudinal studies; obesity; perimenopause; physical activity

Contributing organizations

Related projects

Related research datasets

Ministry reportingYes

Reporting Year2022

JUFO rating2

Last updated on 2024-15-06 at 21:07