A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Menopause modulates the circulating metabolome : evidence from a prospective cohort study (2022)

Karppinen, J. E., Törmäkangas, T., Kujala, U. M., Sipilä, S., Laukkanen, J., Aukee, P., Kovanen, V., & Laakkonen, E. K. (2022). Menopause modulates the circulating metabolome : evidence from a prospective cohort study. European Journal of Preventive Cardiology, 29(10), 1448-1459. https://doi.org/10.1093/eurjpc/zwac060

JYU-tekijät tai -toimittajat

Karppinen, Jari
Törmäkangas, Timo
Kujala, Urho
Sipilä, Sarianna
Laukkanen, Jari
Kovanen, Vuokko
Laakkonen, Eija

Julkaisun tiedot

Julkaisun kaikki tekijät tai toimittajat: Karppinen, Jari E.; Törmäkangas, Timo; Kujala, Urho M.; Sipilä, Sarianna; Laukkanen, Jari; Aukee, Pauliina; Kovanen, Vuokko; Laakkonen, Eija K.

Lehti tai sarja: European Journal of Preventive Cardiology

ISSN: 2047-4873

eISSN: 2047-4881

Julkaisuvuosi: 2022

Ilmestymispäivä: 12.05.2022

Volyymi: 29

Lehden numero: 10

Artikkelin sivunumerot: 1448-1459

Kustantaja: Oxford University Press (OUP)

Julkaisumaa: Britannia

Julkaisun kieli: englanti

DOI: https://doi.org/10.1093/eurjpc/zwac060

Pysyvä verkko-osoite: https://academic.oup.com/eurjpc/advance-article/doi/10.1093/eurjpc/zwac060/6580397

Julkaisun avoin saatavuus: Avoimesti saatavilla

Julkaisukanavan avoin saatavuus: Osittain avoin julkaisukanava

Julkaisu on rinnakkaistallennettu (JYX): https://jyx.jyu.fi/handle/123456789/82724

Tiivistelmä

Aims
We studied the changes in the circulating metabolome and their relation to the menopausal hormonal shift in 17β-oestradiol and follicle-stimulating hormone levels among women transitioning from perimenopause to early postmenopause.

Methods and results
We analysed longitudinal data from 218 Finnish women, 35 of whom started menopausal hormone therapy during the study. The menopausal transition was monitored with menstrual diaries and serum hormone measurements. The median follow-up was 14 months (interquartile range: 8–20). Serum metabolites were quantified with targeted nuclear magnetic resonance metabolomics. The model results were adjusted for age, follow-up duration, education, lifestyle, and multiple comparisons. Menopause was associated with 85 metabolite measures. The concentration of apoB (0.17 standard deviation [SD], 99.5% confidence interval [CI] 0.03–0.31), very-low-density lipoprotein triglycerides (0.25 SD, CI 0.05–0.45) and particles (0.21 SD, CI 0.05–0.36), low-density lipoprotein (LDL) cholesterol (0.17 SD, CI 0.01–0.34) and particles (0.17 SD, CI 0.03–0.31), high-density lipoprotein (HDL) triglycerides (0.24 SD, CI 0.02–0.46), glycerol (0.32 SD, CI 0.07–0.58) and leucine increased (0.25 SD, CI 0.02–0.49). Citrate (−0.36 SD, CI −0.57 to −0.14) and 3-hydroxybutyrate concentrations decreased (−0.46 SD, CI −0.75 to −0.17). Most metabolite changes were associated with the menopausal hormonal shift. This explained 11% and 9% of the LDL cholesterol and particle concentration increase, respectively. Menopausal hormone therapy was associated with increased medium-to-large HDL particle count and decreased small-to-medium LDL particle and glycine concentration.

Conclusions
Menopause is associated with proatherogenic circulating metabolome alterations. Female sex hormones levels are connected to the alterations, highlighting their impact on women’s cardiovascular health.

YSO-asiasanat: aineenvaihdunta; aineenvaihduntahäiriöt; aineenvaihduntatuotteet; sydän- ja verisuonitaudit; hormonaaliset tekijät; vaihdevuodet; hormonihoito; estradioli; kohorttitutkimus