A1 Journal article (refereed)
Hippocampal responses to electrical stimulation of the major input pathways are modulated by dentate spikes (2022)


Lehtonen, S., Waselius, T., Penttonen, M., & Nokia, M. S. (2022). Hippocampal responses to electrical stimulation of the major input pathways are modulated by dentate spikes. Hippocampus, 32(11-12), 808-817. https://doi.org/10.1002/hipo.23470


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Publication details

All authors or editorsLehtonen, Suvi‐Maaria; Waselius, Tomi; Penttonen, Markku; Nokia, Miriam S.

Journal or seriesHippocampus

ISSN1050-9631

eISSN1098-1063

Publication year2022

Publication date16/09/2022

Volume32

Issue number11-12

Pages range808-817

PublisherJohn Wiley & Sons

Publication countryUnited States

Publication languageEnglish

DOIhttps://doi.org/10.1002/hipo.23470

Publication open accessOpenly available

Publication channel open accessPartially open access channel

Publication is parallel published (JYX)https://jyx.jyu.fi/handle/123456789/83278


Abstract

Dentate gyrus (DG) is important for pattern separation and spatial memory, and it is thought to gate information flow to the downstream hippocampal subregions. Dentate spikes (DSs) are high-amplitude, fast, positive local-field potential events taking place in the DG during immobility and sleep, and they have been connected to memory consolidation in rodents. DSs are a result of signaling from the entorhinal cortex (EC) to the DG, and they suppress firing of pyramidal cells in the CA3 and CA1. To study the effects of DSs to signaling in the hippocampal tri-synaptic loop, we electrically stimulated the afferent fibers of the DG, CA3, and CA1 in adult male Sprague–Dawley rats at different delays from DSs. Responses to stimulation were increased in the EC-DG synapse during DSs, and the effect was amplified after theta-burst stimulation. We concluded that DSs strengthen the excitatory signal from the EC to the DG, which is reinforced by synapse potentiation and increased excitability of granule cells after theta-burst stimulation. This signal boosting may function in enhancing plastic changes in the DG-CA3 synapse. As responses in the CA3 and CA1 remained unaffected by the DS, the DS-contingent silencing of pyramidal cells seems to be a result of a decrease in excitatory input rather than a decrease in the excitability of the pyramidal cells themselves. In addition, we found that the DSs occur asynchronously in the left and right hippocampi, giving novel evidence of lateralization of the rodent hippocampus.


Keywordselectrophysiologyhippocampusmemory (cognition)braincerebral cortex

Free keywordsdentate gyrus; electrophysiology; hippocampus; lateralization; synaptic transmission


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Ministry reportingYes

Reporting Year2022

JUFO rating1


Last updated on 2024-03-04 at 21:46