A1 Journal article (refereed)
SAP30L interacts with members of the Sin3A corepressor complex and targets Sin3A to the nucleolus (2006)

Viiri, K., Korkeamäki, H., Kukkonen, M., Nieminen, L., Lindfors, K., Peterson, P., Mäki, M., Kainulainen, H., & Lohi, O. (2006). SAP30L interacts with members of the Sin3A corepressor complex and targets Sin3A to the nucleolus. Nucleic Acids Research, 34(11), 3288-3298. https://doi.org/10.1093/nar/gkl401

JYU authors or editors

Publication details

All authors or editorsViiri, Keijo; Korkeamäki, Hanna; Kukkonen, Mari; Nieminen, Laura; Lindfors, Katri; Peterson, Pert; Mäki, Markku; Kainulainen, Heikki; Lohi, Olli

Journal or seriesNucleic Acids Research



Publication year2006


Issue number11

Pages range3288-3298

PublisherOxford University Press

Publication languageEnglish


Publication open accessNot open

Publication channel open access

Publication is parallel published (JYX)https://jyx.jyu.fi/handle/123456789/82811

Additional informationdoi: 10.1093/nar/gkl401


Histone acetylation plays a key role in the regulation of gene expression. The chromatin structure and accessibility of genes to transcription factors is regulated by enzymes that acetylate and deacetylate histones. The Sin3A corepressor complex recruits histone deacetylases and in many cases represses transcription. Here, we report that SAP30L, a close homolog of Sin3-associated protein 30 (SAP30), interacts with several components of the Sin3A corepressor complex. We show that it binds to the PAH3/HID (Paired Amphipathic Helix 3/Histone deacetylase Interacting Domain) region of mouse Sin3A with residues 120–140 in the C-terminal part of the protein. We provide evidence that SAP30L induces transcriptional repression, possibly via recruitment of Sin3A and histone deacetylases. Finally, we characterize a functional nucleolar localization signal in SAP30L and show that SAP30L and SAP30 are able to target Sin3A to the nucleolus.

Keywordsgenesproteinsenzymesinteractiontranscription (biological events)biochemistry

Free keywordsHistone deacetylation; nucleolus; Sin-associated proteins

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Ministry reportingYes

Preliminary JUFO ratingNot rated

Last updated on 2024-08-01 at 19:26