A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Genotype determining aerobic exercise capacity associates with behavioral plasticity in middle-aged rats (2023)

Mäkinen, E., Wikgren, J., Pekkala, S., Koch, L. G., Britton, S. L., Nokia, M. S., & Lensu, S. (2023). Genotype determining aerobic exercise capacity associates with behavioral plasticity in middle-aged rats. Behavioural Brain Research, 443, Article 114331. https://doi.org/10.1016/j.bbr.2023.114331

JYU-tekijät tai -toimittajat

Mäkinen, Elina
Wikgren, Jan
Pekkala, Satu
Nokia, Miriam
Lensu, Sanna

Julkaisun tiedot

Julkaisun kaikki tekijät tai toimittajat: Mäkinen, Elina; Wikgren, Jan; Pekkala, Satu; Koch, Lauren G.; Britton, Steven L.; Nokia, Miriam S.; Lensu, Sanna

Lehti tai sarja: Behavioural Brain Research

ISSN: 0166-4328

eISSN: 1872-7549

Julkaisuvuosi: 2023

Ilmestymispäivä: 10.02.2023

Volyymi: 443

Artikkelinumero: 114331

Kustantaja: Elsevier BV

Julkaisumaa: Alankomaat

Julkaisun kieli: englanti

DOI: https://doi.org/10.1016/j.bbr.2023.114331

Julkaisun avoin saatavuus: Avoimesti saatavilla

Julkaisukanavan avoin saatavuus: Osittain avoin julkaisukanava

Julkaisu on rinnakkaistallennettu (JYX): https://jyx.jyu.fi/handle/123456789/85656

Tiivistelmä

Good aerobic fitness associates positively with cognitive performance and brain health and conversely, low aerobic fitness predisposes to neurodegenerative diseases. To study how genotype together with exercise, started at older age, affects brain and behavior, we utilized rats that differ in inherited aerobic fitness. Rats bred for Low Capacity for Running (LCR) are shown to display less synaptic plasticity and more inflammation in the hippocampus and perform worse than rats bred for a High Capacity for Running (HCR) in tasks requiring flexible cognition. Here we used middle-aged (∼ 16 months) HCR and LCR rats to study how genotype and sex associate with anxiety and neural information filtering, termed sensory gating. Further, we assessed how inherited aerobic capacity associates with hippocampus-dependent learning, measured with contextual fear conditioning task. In females, we also investigated the effects of voluntary wheel running (5 weeks) on these characteristics. Our results indicate that independent of sex or voluntary running, HCR rats were more anxious in open-field tasks, exhibited lower sensory gating and learned more efficiently in contextual fear conditioning task than LCR rats. Voluntary running did not markedly affect innate behavior but slightly decreased the differences between female LCR and HCR rats in fear learning. In conclusion, inherited fitness seems to determine cognitive and behavioral traits independent of sex. Although the traits proved to be rather resistant to change at adult age, learning was slightly improved following exercise in LCR females, prone to obesity and poor fitness.

YSO-asiasanat: genotyyppi; fyysinen aktiivisuus; aerobinen suorituskyky; kognitio; ahdistus; muisti (kognitio); käyttäytyminen; koe-eläinmallit

Vapaat asiasanat: fear conditioning; open field; pre-pulse inhibition; running capacity; learning; exercise; anxiety; memory

Liittyvät organisaatiot

Hankkeet, joissa julkaisu on tehty

Liittyvät tutkimusaineistot

OKM-raportointi: Kyllä

VIRTA-lähetysvuosi: 2023

JUFO-taso: 1