A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Age but not menopausal status is linked to lower resting energy expenditure (2023)


Karppinen, J. E., Wiklund, P., Ihalainen, J. K., Juppi, H.-K., Isola, V., Hyvärinen, M., Ahokas, E. K., Kujala, U. M., Laukkanen, J., Hulmi, J. J., Ahtiainen, J. P., Cheng, S., & Laakkonen, E. K. (2023). Age but not menopausal status is linked to lower resting energy expenditure. Journal of Clinical Endocrinology and Metabolism, 108(11), 2789-2797. https://doi.org/10.1210/clinem/dgad321


JYU-tekijät tai -toimittajat


Julkaisun tiedot

Julkaisun kaikki tekijät tai toimittajatKarppinen, Jari E.; Wiklund, Petri; Ihalainen, Johanna K.; Juppi, Hanna-Kaarina; Isola, Ville; Hyvärinen, Matti; Ahokas, Essi K.; Kujala, Urho M.; Laukkanen, Jari; Hulmi, Juha J.; et al.

Lehti tai sarjaJournal of Clinical Endocrinology and Metabolism

ISSN0021-972X

eISSN1945-7197

Julkaisuvuosi2023

Ilmestymispäivä02.06.2023

Volyymi108

Lehden numero11

Artikkelin sivunumerot2789-2797

KustantajaOxford University Press; The Endocrine Society

JulkaisumaaYhdysvallat (USA)

Julkaisun kielienglanti

DOIhttps://doi.org/10.1210/clinem/dgad321

Julkaisun avoin saatavuusAvoimesti saatavilla

Julkaisukanavan avoin saatavuusOsittain avoin julkaisukanava

Julkaisu on rinnakkaistallennettu (JYX)https://jyx.jyu.fi/handle/123456789/90875

Rinnakkaistallenteen verkko-osoite (pre-print)https://www.biorxiv.org/content/10.1101/2022.12.16.520683v1


Tiivistelmä

Context
It remains uncertain whether aging before late adulthood and menopause are associated with fat-free mass and fat mass–adjusted resting energy expenditure (REEadj).

Objectives
We investigated whether REEadj differs between middle-aged and younger women and between middle-aged women with different menopausal statuses. We repeated the age group comparison between middle-aged mothers and their daughters to partially control for genotype. We also explored whether serum estradiol and follicle-stimulating hormone concentrations explain REEadj in midlife.

Methods
We divided 120 women, including 16 mother–daughter pairs, into age groups; group I (n=26) consisted of participants aged 17–21, group II (n=35) of those aged 22–38 and group III (n=59) of those aged 41–58 years. The women in group III were further categorized as pre- or perimenopausal (n=19), postmenopausal (n=30) or postmenopausal hormone therapy users (n=10). REE was assessed using indirect calorimetry, body composition using dual-energy X-ray absorptiometry and hormones using immunoassays.

Results
The REEadj of group I was 126 kcal/d (95% CI: 93–160) higher than that of group III, and the REEadj of group II was 88 kcal/d (95% CI: 49–127) higher. Furthermore, daughters had a 100 kcal/d (95% CI: 63–138 kcal/d) higher REEadj than their middle-aged mothers (all P<0.001). In group III, REEadj was not lower in postmenopausal women and did not vary by sex hormone concentrations.

Conclusions
We demonstrated that REEadj declines with age in women before late adulthood, also when controlling partially for genetic background, and that menopause may not contribute to this decline.


YSO-asiasanatenergiankulutus (aineenvaihdunta)hormonaaliset tekijätestrogeenitvaihdevuodethormonihoitoikääntyminennaiset

Vapaat asiasanatresting energy expenditure; menopause; estrogen; hormone replacement therapy


Liittyvät organisaatiot


Hankkeet, joissa julkaisu on tehty


Liittyvät tutkimusaineistot


OKM-raportointiKyllä

Raportointivuosi2023

JUFO-taso3


Viimeisin päivitys 2024-15-06 klo 21:26