A1 Journal article (refereed)
Genome-Wide Polygenic Score for Muscle Strength Predicts Risk for Common Diseases and Lifespan : A Prospective Cohort Study (2024)

Herranen, Päivi, Koivunen, Kaisa, Palviainen, Teemu, Kujala, Urho M., Ripatti, Samuli, Kaprio, Jaakko, Sillanpää, Elina, FinnGen. (2024). Genome-Wide Polygenic Score for Muscle Strength Predicts Risk for Common Diseases and Lifespan : A Prospective Cohort Study. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 79(4), Article glae064. https://doi.org/10.1093/gerona/glae064

JYU authors or editors

Publication details

All authors or editorsHerranen, Päivi; Koivunen, Kaisa; Palviainen, Teemu; Kujala, Urho M.; Ripatti, Samuli; Kaprio, Jaakko; Sillanpää, Elina; FinnGen

Journal or seriesJournals of Gerontology Series A: Biological Sciences and Medical Sciences



Publication year2024

Publication date07/03/2024


Issue number4

Article numberglae064

PublisherOxford University Press (OUP)

Publication countryUnited States

Publication languageEnglish


Publication open accessOpenly available

Publication channel open accessPartially open access channel

Publication is parallel published (JYX)https://jyx.jyu.fi/handle/123456789/94350


We used a polygenic score for hand grip strength (PGS HGS) to investigate whether genetic predisposition for higher muscle strength predicts age-related noncommunicable diseases, survival from acute adverse health events, and mortality.

This study consisted of 342 443 Finnish biobank participants from FinnGen Data Freeze 10 (53% women) aged 40 to 108 with combined genotype and health registry data. Associations between PGS HGS and a total of 27 clinical endpoints were explored with linear or Cox regression models.

A higher PGS HGS was associated with a reduced risk of selected common noncommunicable diseases and mortality by 2% to 10%. The risk for these medical conditions decreased by 5–23% for participants in the highest PGS HGS quintile compared to those in the lowest PGS HGS quintile. A one standard deviation (SD) increase in the PGS HGS predicted a lower body mass index (BMI) (β = −0.112 kg/m2, standard error (SE) = 0.017, P = 1.69E-11) in women but not in men (β = 0.004 kg/m2, P = 0.768). PGS HGS was not associated with better survival after acute adverse health events compared to the non-diseased period.

The genotype that supports higher muscle strength appears to protect against future health adversities, albeit with modest effect sizes. Further research is needed to investigate whether or how a favourable lifestyle modifies this intrinsic capacity to resist diseases, and if the impacts of lifestyle behaviour on health differ due to genetic predisposition for muscle strength.

Keywordsgeneticspress forceforecasts

Free keywordsgenetics; hand grip strength; prediction; noncommunicable diseases; FinnGen

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Ministry reportingYes

Reporting Year2024

Preliminary JUFO rating3

Last updated on 2024-13-05 at 18:26