A1 Journal article (refereed)
Distinct Hippocampal Oscillation Dynamics in Trace Eyeblink Conditioning Task for Retrieval and Consolidation of Associations (2024)
Kim, K., Nokia, M. S., & Palva, S. (2024). Distinct Hippocampal Oscillation Dynamics in Trace Eyeblink Conditioning Task for Retrieval and Consolidation of Associations. eNeuro, 11(4), Article ENEURO.0030-23.2024. https://doi.org/10.1523/ENEURO.0030-23.2024
JYU authors or editors
Publication details
All authors or editors: Kim, Kayeon; Nokia, Miriam S.; Palva, Satu
Journal or series: eNeuro
eISSN: 2373-2822
Publication year: 2024
Publication date: 16/04/2024
Volume: 11
Issue number: 4
Article number: ENEURO.0030-23.2024
Publisher: Society for Neuroscience
Publication country: United States
Publication language: English
DOI: https://doi.org/10.1523/ENEURO.0030-23.2024
Publication open access: Openly available
Publication channel open access: Open Access channel
Publication is parallel published (JYX): https://jyx.jyu.fi/handle/123456789/94869
Publication is parallel published: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11046259/
Abstract
Trace eyeblink conditioning (TEBC) has been widely used to study associative learning in both animals and humans. In this paradigm, conditioned responses (CRs) to conditioned stimuli (CS) serve as a measure for retrieving learned associations between the CS and the unconditioned stimuli (US) within a trial. Memory consolidation, that is, learning over time, can be quantified as an increase in the proportion of CRs across training sessions. However, how hippocampal oscillations differentiate between successful memory retrieval within a session and consolidation across TEBC training sessions remains unknown. To address this question, we recorded local field potentials (LFPs) from the rat dorsal hippocampus during TEBC and investigated hippocampal oscillation dynamics associated with these two functions. We show that transient broadband responses to the CS were correlated with memory consolidation, as indexed by an increase in CRs across TEBC sessions. In contrast, induced alpha (8–10 Hz) and beta (16–20 Hz) band responses were correlated with the successful retrieval of the CS–US association within a session, as indexed by the difference in trials with and without CR.
Keywords: hippocampus; oscillations; learning; association (cognitive processes); conditioning (passive); memory (cognition); cognitive processes
Free keywords: classical conditioning; cross-frequency; coupling; hippocampus; memory; phase locking
Contributing organizations
Related projects
- Hippocampal oscillations and associative learning: Stepping out of the maze and exploring new waves
- Nokia, Miriam
- Research Council of Finland
- Optimizing learning - synchrony of the brain and body as a tool?
- Nokia, Miriam
- Research Council of Finland
Ministry reporting: Yes
VIRTA submission year: 2024
Preliminary JUFO rating: 1