A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Distinct Hippocampal Oscillation Dynamics in Trace Eyeblink Conditioning Task for Retrieval and Consolidation of Associations (2024)

Kim, K., Nokia, M. S., & Palva, S. (2024). Distinct Hippocampal Oscillation Dynamics in Trace Eyeblink Conditioning Task for Retrieval and Consolidation of Associations. eNeuro, 11(4), Article ENEURO.0030-23.2024. https://doi.org/10.1523/ENEURO.0030-23.2024

JYU-tekijät tai -toimittajat

Nokia, Miriam

Julkaisun tiedot

Julkaisun kaikki tekijät tai toimittajat: Kim, Kayeon; Nokia, Miriam S.; Palva, Satu

Lehti tai sarja: eNeuro

eISSN: 2373-2822

Julkaisuvuosi: 2024

Ilmestymispäivä: 16.04.2024

Volyymi: 11

Lehden numero: 4

Artikkelinumero: ENEURO.0030-23.2024

Kustantaja: Society for Neuroscience

Julkaisumaa: Yhdysvallat (USA)

Julkaisun kieli: englanti

DOI: https://doi.org/10.1523/ENEURO.0030-23.2024

Julkaisun avoin saatavuus: Avoimesti saatavilla

Julkaisukanavan avoin saatavuus: Kokonaan avoin julkaisukanava

Julkaisu on rinnakkaistallennettu (JYX): https://jyx.jyu.fi/handle/123456789/94869

Julkaisu on rinnakkaistallennettu: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11046259/

Tiivistelmä

Trace eyeblink conditioning (TEBC) has been widely used to study associative learning in both animals and humans. In this paradigm, conditioned responses (CRs) to conditioned stimuli (CS) serve as a measure for retrieving learned associations between the CS and the unconditioned stimuli (US) within a trial. Memory consolidation, that is, learning over time, can be quantified as an increase in the proportion of CRs across training sessions. However, how hippocampal oscillations differentiate between successful memory retrieval within a session and consolidation across TEBC training sessions remains unknown. To address this question, we recorded local field potentials (LFPs) from the rat dorsal hippocampus during TEBC and investigated hippocampal oscillation dynamics associated with these two functions. We show that transient broadband responses to the CS were correlated with memory consolidation, as indexed by an increase in CRs across TEBC sessions. In contrast, induced alpha (8–10 Hz) and beta (16–20 Hz) band responses were correlated with the successful retrieval of the CS–US association within a session, as indexed by the difference in trials with and without CR.

YSO-asiasanat: hippokampus; värähtelyt; oppiminen; assosiaatio; ehdollistuminen; muisti (kognitio); kognitiiviset prosessit