A1 Journal article (refereed)
Distinct Hippocampal Oscillation Dynamics in Trace Eyeblink Conditioning Task for Retrieval and Consolidation of Associations (2024)

Kim, K., Nokia, M. S., & Palva, S. (2024). Distinct Hippocampal Oscillation Dynamics in Trace Eyeblink Conditioning Task for Retrieval and Consolidation of Associations. eNeuro, 11(4), Article ENEURO.0030-23.2024. https://doi.org/10.1523/ENEURO.0030-23.2024

JYU authors or editors

Publication details

All authors or editors: Kim, Kayeon; Nokia, Miriam S.; Palva, Satu

Journal or series: eNeuro

eISSN: 2373-2822

Publication year: 2024

Publication date: 16/04/2024

Volume: 11

Issue number: 4

Article number: ENEURO.0030-23.2024

Publisher: Society for Neuroscience

Publication country: United States

Publication language: English

DOI: https://doi.org/10.1523/ENEURO.0030-23.2024

Publication open access: Openly available

Publication channel open access: Open Access channel

Publication is parallel published (JYX): https://jyx.jyu.fi/handle/123456789/94869

Publication is parallel published: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11046259/

Abstract

Trace eyeblink conditioning (TEBC) has been widely used to study associative learning in both animals and humans. In this paradigm, conditioned responses (CRs) to conditioned stimuli (CS) serve as a measure for retrieving learned associations between the CS and the unconditioned stimuli (US) within a trial. Memory consolidation, that is, learning over time, can be quantified as an increase in the proportion of CRs across training sessions. However, how hippocampal oscillations differentiate between successful memory retrieval within a session and consolidation across TEBC training sessions remains unknown. To address this question, we recorded local field potentials (LFPs) from the rat dorsal hippocampus during TEBC and investigated hippocampal oscillation dynamics associated with these two functions. We show that transient broadband responses to the CS were correlated with memory consolidation, as indexed by an increase in CRs across TEBC sessions. In contrast, induced alpha (8–10 Hz) and beta (16–20 Hz) band responses were correlated with the successful retrieval of the CS–US association within a session, as indexed by the difference in trials with and without CR.

Keywords: hippocampus; oscillations; learning; association (cognitive processes); conditioning (passive); memory (cognition); cognitive processes

Free keywords: classical conditioning; cross-frequency; coupling; hippocampus; memory; phase locking

Contributing organizations

Related projects

Ministry reporting: Yes

Reporting Year: 2024

Preliminary JUFO rating: 1