A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Genetic Liability to Cardiovascular Disease, Physical Activity, and Mortality : Findings from the Finnish Twin Cohort (2024)


Joensuu, L., Waller, K., Kankaanpää, A., Palviainen, T., Kaprio, J., & Sillanpää, E. (2024). Genetic Liability to Cardiovascular Disease, Physical Activity, and Mortality : Findings from the Finnish Twin Cohort. Medicine and Science in Sports and Exercise, Ahead of Print. https://doi.org/10.1249/mss.0000000000003482


JYU-tekijät tai -toimittajat


Julkaisun tiedot

Julkaisun kaikki tekijät tai toimittajat: Joensuu, Laura; Waller, Katja; Kankaanpää, Anna; Palviainen, Teemu; Kaprio, Jaakko; Sillanpää, Elina

Lehti tai sarja: Medicine and Science in Sports and Exercise

ISSN: 0195-9131

eISSN: 1530-0315

Julkaisuvuosi: 2024

Ilmestymispäivä: 15.05.2024

Volyymi: Ahead of Print

Kustantaja: Lippincott Williams & Wilkins

Julkaisumaa: Yhdysvallat (USA)

Julkaisun kieli: englanti

DOI: https://doi.org/10.1249/mss.0000000000003482

Julkaisun avoin saatavuus: Ei avoin

Julkaisukanavan avoin saatavuus: 

Julkaisu on rinnakkaistallennettu (JYX): https://jyx.jyu.fi/handle/123456789/95323

Rinnakkaistallenteen verkko-osoite (pre-print): https://www.medrxiv.org/content/10.1101/2023.04.28.23289250v1


Tiivistelmä

Purpose
We investigated whether longitudinally assessed physical activity (PA) and adherence specifically to World Health Organization PA guidelines mitigates or moderates mortality risk regardless of genetic liability to cardiovascular disease (CVD). We also estimated the causality of the PA-mortality association.

Methods
The study used the older Finnish Twin Cohort (FTC) with 4,897 participants aged 33–60 years (54.3% women). Genetic liability to coronary heart disease, systolic and diastolic blood pressure was estimated with polygenic risk scores (PRSs) derived from the Pan-UK Biobank (N ≈ 400,000; > 1,000,000 genetic variants). Leisure-time PA was assessed with validated and structured questionnaires three times during 1975–1990. The main effects of adherence to PA guidelines and the PRS × PA interactions were evaluated with Cox proportional hazards models against all-cause and CVD mortality. A co-twin control design with 180 monozygotic twin pairs discordant for meeting the guidelines was used for causal inference.

Results
During the 17.4-year (mean) follow-up (85,136 person-years), 1,195 participants died, with 389 CVD deaths. One standard deviation higher PRSs were associated with a 17%–24% higher CVD mortality risk but not with all-cause mortality except for the PRS for diastolic blood pressure. Adherence to PA guidelines did not show significant independent main effects or interactions with all-cause or CVD mortality. Twins whose activity levels adhered to PA guidelines over a 15-year period did not have statistically significantly reduced mortality risk compared to their less active identical twin sibling. The findings were similar among high, intermediate, and low genetic risk levels for CVD.

Conclusions
The genetically informed FTC data could not confirm that adherence to PA guidelines either mitigates or moderates genetic CVD risk or causally reduces mortality risk.


YSO-asiasanat: kuntoliikunta; terveyden edistäminen; kansanterveys; sydän- ja verisuonitaudit

Vapaat asiasanat: exercise; genetic epidemiology; health promotion; public health


Liittyvät organisaatiot


Hankkeet, joissa julkaisu on tehty


OKM-raportointi: Kyllä

Alustava JUFO-taso: 3


Viimeisin päivitys 2024-29-05 klo 13:34