A1 Journal article (refereed)
Intensity dependence of auditory evoked potentials distinguish participants with unmedicated depression from non‐depressed controls (2024)

Kangas, E. S., Li, X., Vuoriainen, E., Lindeman, S., & Astikainen, P. (2024). Intensity dependence of auditory evoked potentials distinguish participants with unmedicated depression from non‐depressed controls. European Journal of Neuroscience, 60(10), 6440-6469. https://doi.org/10.1111/ejn.16569

JYU authors or editors

Publication details

All authors or editors: Kangas, Elina S.; Li, Xueqiao; Vuoriainen, Elisa; Lindeman, Sari; Astikainen, Piia

Journal or series: European Journal of Neuroscience

ISSN: 0953-816X

eISSN: 1460-9568

Publication year: 2024

Publication date: 14/10/2024

Volume: 60

Issue number: 10

Pages range: 6440-6469

Publisher: Wiley

Publication country: United Kingdom

Publication language: English

DOI: https://doi.org/10.1111/ejn.16569

Publication open access: Openly available

Publication channel open access: Partially open access channel

Publication is parallel published (JYX): https://jyx.jyu.fi/handle/123456789/97502

Abstract

Depression is a heterogeneous syndrome that impacts an individual's emotional, social, cognitive and bodily functioning. Depression is associated with biases in emotional processing, but alterations in basic sensory processing have received less attention in depression research. Here, we measured event-related potentials (ERPs) in response to changes in the intensity of auditory stimuli and the location of somatosensory stimuli in participants with depression and in non-depressed control participants. We tested whether auditory mismatch negativity, P3a or N1 intensity dependence response or somatosensory mismatch response, P3a, P50 or N80 can dissociate depressed participants and non-depressed controls, and we also analysed the effects of depression medication and age in this sample. N1 intensity dependence response was increased in unmedicated depressed participants relative to non-depressed controls. When age was controlled for in the analysis, the effect of depression was only at a trend level. N1 intensity dependence response correlated with depression severity at the whole sample level. We did not observe any depression-related alterations in auditory mismatch negativity or P3a or somatosensory ERPs. Our results may reflect an association between the N1 intensity dependence response and altered neurotransmitter activity in depression, but this should be confirmed in future studies.

Keywords: depression (mental disorders); mental disorders; emotional disorders; auditory perceptions; sound intensity; neurosciences; psychophysiology

Free keywords: auditory; depression; event-related potentials; intensity dependence; somatosensory

Contributing organizations

Related projects

Ministry reporting: Yes

VIRTA submission year: 2024

Preliminary JUFO rating: 2