A1 Journal article (refereed)
Effects of aerobic and strength training on aerobic capacity, muscle strength, and gene expression of lymphomonocytes in patients with stable CAD (2020)

Lehti, M., Valkeinen, H., Sipilä, S., Perhonen, M., Rottensteiner, M., Pullinen, T., Pietiläinen, R., Nyman, K., Vehkaoja, A., Kainulainen, H., & Kujala, U. M. (2020). Effects of aerobic and strength training on aerobic capacity, muscle strength, and gene expression of lymphomonocytes in patients with stable CAD. American Journal of Translational Research, 12(8), 4582-4593. http://www.ajtr.org/files/ajtr0107339.pdf

JYU authors or editors

Publication details

All authors or editorsLehti, Maarit; Valkeinen, Heli; Sipilä, Sarianna; Perhonen, Merja; Rottensteiner, Mirva; Pullinen, Teemu; Pietiläinen, Rauno; Nyman, Kai; Vehkaoja, Antti; Kainulainen, Heikki; et al.

Journal or seriesAmerican Journal of Translational Research


Publication year2020


Issue number8

Pages range4582-4593

Publishere-Century Publishing Corporation

Publication countryUnited States

Publication languageEnglish

Persistent website addresshttp://www.ajtr.org/files/ajtr0107339.pdf

Publication open accessOpenly available

Publication channel open accessOpen Access channel

Publication is parallel published (JYX)https://jyx.jyu.fi/handle/123456789/72088

Publication is parallel publishedhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7476147/


This study examined the effectiveness, suitability, and safety of a mixed interval-type aerobic and strength training program (MIAST) on physical fitness in patients with stable coronary artery disease (CAD) without history of myocardial infarction (MI). Twenty-three patients with stable CAD were randomly assigned to a MIAST (n = 12; mean age 58.6 years) or control (n = 11; 63.3 years) group. The MIAST group participated in the progressive training program twice a week for 21 weeks. Peak oxygen uptake (VO2peak), workload, and exercise time were measured as were maximal muscle strength, serum lipids, glucose concentration, and the cross-sectional area (CSA) of knee extensors. The safety and suitability of the program were assessed by wireless electrocardiogram (ECG) monitoring and exercise diaries. VO2peak (6.9%; P < 0.05) and exercise time (11.2%; P < 0.05) improved significantly after 12 weeks of training in the MIAST group compared to the control group. Muscle strength (19.9%; P < 0.05) and CSA (2.2%; P < 0.05) increased, and serum lipids and blood glucose tended to decrease after the training. The successful training program (increase in maximal oxygen uptake) increased the gene expression of oxygen metabolism and decreased the gene expression of inflammation pathways in lymphomonocytes. The MIAST program, including interval-type aerobic and strength training, was safe, did not cause any adverse effects, and led to significant improvements in physical fitness in patients with stable CAD.

Keywordscoronary diseasepatientsphysical fitnessoxygen uptakemaximal oxygen uptakemuscle strengthexercise therapyendurance trainingstrength training

Free keywordscoronary heart disease; physical fitness; oxygen consumption; endurance training; resistance training

Contributing organizations

Ministry reportingYes

Reporting Year2020

JUFO rating1

Last updated on 2024-03-04 at 20:46