A1 Journal article (refereed)
Effects of aerobic and strength training on aerobic capacity, muscle strength, and gene expression of lymphomonocytes in patients with stable CAD (2020)
Lehti, M., Valkeinen, H., Sipilä, S., Perhonen, M., Rottensteiner, M., Pullinen, T., Pietiläinen, R., Nyman, K., Vehkaoja, A., Kainulainen, H., & Kujala, U. M. (2020). Effects of aerobic and strength training on aerobic capacity, muscle strength, and gene expression of lymphomonocytes in patients with stable CAD. American Journal of Translational Research, 12(8), 4582-4593. http://www.ajtr.org/files/ajtr0107339.pdf
JYU authors or editors
Publication details
All authors or editors: Lehti, Maarit; Valkeinen, Heli; Sipilä, Sarianna; Perhonen, Merja; Rottensteiner, Mirva; Pullinen, Teemu; Pietiläinen, Rauno; Nyman, Kai; Vehkaoja, Antti; Kainulainen, Heikki; et al.
Journal or series: American Journal of Translational Research
eISSN: 1943-8141
Publication year: 2020
Volume: 12
Issue number: 8
Pages range: 4582-4593
Publisher: e-Century Publishing Corporation
Publication country: United States
Publication language: English
Persistent website address: http://www.ajtr.org/files/ajtr0107339.pdf
Publication open access: Openly available
Publication channel open access: Open Access channel
Publication is parallel published (JYX): https://jyx.jyu.fi/handle/123456789/72088
Publication is parallel published: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7476147/
Abstract
This study examined the effectiveness, suitability, and safety of a mixed interval-type aerobic and strength training program (MIAST) on physical fitness in patients with stable coronary artery disease (CAD) without history of myocardial infarction (MI). Twenty-three patients with stable CAD were randomly assigned to a MIAST (n = 12; mean age 58.6 years) or control (n = 11; 63.3 years) group. The MIAST group participated in the progressive training program twice a week for 21 weeks. Peak oxygen uptake (VO2peak), workload, and exercise time were measured as were maximal muscle strength, serum lipids, glucose concentration, and the cross-sectional area (CSA) of knee extensors. The safety and suitability of the program were assessed by wireless electrocardiogram (ECG) monitoring and exercise diaries. VO2peak (6.9%; P < 0.05) and exercise time (11.2%; P < 0.05) improved significantly after 12 weeks of training in the MIAST group compared to the control group. Muscle strength (19.9%; P < 0.05) and CSA (2.2%; P < 0.05) increased, and serum lipids and blood glucose tended to decrease after the training. The successful training program (increase in maximal oxygen uptake) increased the gene expression of oxygen metabolism and decreased the gene expression of inflammation pathways in lymphomonocytes. The MIAST program, including interval-type aerobic and strength training, was safe, did not cause any adverse effects, and led to significant improvements in physical fitness in patients with stable CAD.
Keywords: coronary artery disease; patients; physical fitness; oxygen uptake; maximal oxygen uptake; muscle strength; exercise therapy; endurance training; strength training
Free keywords: coronary heart disease; physical fitness; oxygen consumption; endurance training; resistance training
Contributing organizations
Ministry reporting: Yes
VIRTA submission year: 2020
JUFO rating: 1