A1 Journal article (refereed)
Neural Mechanisms Underlying Human Auditory Evoked Responses Revealed By Human Neocortical Neurosolver (2022)

Kohl, C., Parviainen, T., & Jones, S. R. (2022). Neural Mechanisms Underlying Human Auditory Evoked Responses Revealed By Human Neocortical Neurosolver. Brain Topography, 35(1), 19-35. https://doi.org/10.1007/s10548-021-00838-0

JYU authors or editors

Publication details

All authors or editors: Kohl, Carmen; Parviainen, Tiina; Jones, Stephanie R.

Journal or series: Brain Topography

ISSN: 0896-0267

eISSN: 1573-6792

Publication year: 2022

Publication date: 19/04/2021

Volume: 35

Issue number: 1

Pages range: 19-35

Publisher: Springer

Publication country: United States

Publication language: English

DOI: https://doi.org/10.1007/s10548-021-00838-0

Publication open access: Openly available

Publication channel open access: Partially open access channel

Publication is parallel published (JYX): https://jyx.jyu.fi/handle/123456789/75241

Abstract

Auditory evoked fields (AEFs) are commonly studied, yet their underlying neural mechanisms remain poorly understood. Here, we used the biophysical modelling software Human Neocortical Neurosolver (HNN) whose foundation is a canonical neocortical circuit model to interpret the cell and network mechanisms contributing to macroscale AEFs elicited by a simple tone, measured with magnetoencephalography. We found that AEFs can be reproduced by activating the neocortical circuit through a layer specific sequence of feedforward and feedback excitatory synaptic drives, similar to prior simulation of somatosensory evoked responses, supporting the notion that basic structures and activation patterns are preserved across sensory regions. We also applied the modeling framework to develop and test predictions on neural mechanisms underlying AEF differences in the left and right hemispheres, as well as in hemispheres contralateral and ipsilateral to the presentation of the auditory stimulus. We found that increasing the strength of the excitatory synaptic cortical feedback inputs to supragranular layers simulates the commonly observed right hemisphere dominance, while decreasing the input latencies and simultaneously increasing the number of cells contributing to the signal accounted for the contralateral dominance. These results provide a direct link between human data and prior animal studies and lay the foundation for future translational research examining the mechanisms underlying alteration in this fundamental biomarker of auditory processing in healthy cognition and neuropathology.

Keywords: auditory perceptions; neural networks (biology); MEG; biophysics; cognitive neuroscience

Free keywords: auditory processing; AEF; MEG; biophysical model; HNN

Contributing organizations

Ministry reporting: Yes

VIRTA submission year: 2022

JUFO rating: 1