Compact Cell-Imaging Device to provide insight into the cellular origins of diseases and to aid in the development of novel therapeutics (CoCID)
Päärahoittaja
Rahoittajan antama koodi/diaarinumero: 101017116
Päärahoittajan myöntämä tuki (€)
- 836 265,00
Rahoitusohjelma
Hankkeen aikataulu
Hankkeen aloituspäivämäärä: 01.01.2021
Hankkeen päättymispäivämäärä: 31.05.2025
Tiivistelmä
Soft x-ray microscopy (SXM) is the unique technology that can image the whole intact cells under normal and pathological conditions without labelling or fixation, at high throughput and spatial resolution. A significant challenge of soft x-ray microscopy is that the photonic illumination required for imaging is currently only available at six football-stadium sized facilities, called synchrotron sources, and only 2% of the disease research community have been able to access this imaging modality.
The challenge addressed by project CoCID is to develop a prototype, lab-scale, soft x-ray microscope, which can be used in a laboratory setting and to demonstrate the feasibility of this extremely valuable imaging modality as a research tool to understand the cellular origin of diseases.
The challenge addressed by project CoCID is to develop a prototype, lab-scale, soft x-ray microscope, which can be used in a laboratory setting and to demonstrate the feasibility of this extremely valuable imaging modality as a research tool to understand the cellular origin of diseases.
Vastuullinen johtaja
Muut hankkeeseen liittyvät henkilöt (JYU)
Päävastuullinen yksikkö
Seurantakohteet
Profiloitumisalue: Nanoscience Center (Fysiikan laitos PHYS, JYFL) (Matemaattis-luonnontieteellinen tiedekunta) (Kemian laitos CHEM) (Bio- ja ympäristötieteiden laitos BIOENV) NSC
Liittyvät julkaisut ja muut tuotokset
- Herpesvirus-Induced Manipulation of the Nucleolus (2024) Leclerc, Simon; et al.; O1; OA
- Mitochondrial Reorganization in Herpesvirus-Infected Cells (2023) Leclerc, S.; et al.; O1; OA
- Soft X-ray Tomography Reveals HSV-1-Induced Remodeling of Human B Cells (2022) Chen, Jian-Hua; et al.; A1; OA
- Compact Cell Imaging Device (CoCID) provides insights into the cellular origins of viral infections (2021) Fahy, Kenneth; et al.; A1; OA
- Infection-induced chromatin modifications facilitate translocation of herpes simplex virus capsids to the inner nuclear membrane (2021) Aho, Vesa; et al.; A1; OA
- Persistence of Human Bocavirus 1 in Tonsillar Germinal Centers and Antibody-Dependent Enhancement of Infection (2021) Xu, Man; et al.; A1; OA
