Hippocampal representation of temporal information
Main funder
Funder's project number: 286384
Funds granted by main funder (€)
- 599 793,00
Funding program
Project timetable
Project start date: 01/09/2015
Project end date: 31/08/2019
Summary
Hippocampus is a brain structure especillay involved in processing spatial information by forming neural maps of the environment. Hippocampal damage impairs the processing of not only spatial but als temporal information leading to various problems in learning and memory. It has been suggested that in addition to place cells, the hippocampus hosts time cells. That is, cells that form neural representations of temporally separate events and sequences. In this project we study whether time cells exist in all hippocampal subregions, how brain structures generally important in regulating hippocampal function affect hippocampal time cell function and how the neural representations formed by time cells are stored into long-term memory. The results will help us better understand hippocampla function and its disturbances. The knowledge can aid in, for example, developing treatments for different memory disorders.
Principal Investigator
Other persons related to this project (JYU)
Primary responsible unit
Keywords (YSO)
Related publications and other outputs
- Irradiation of the head reduces adult hippocampal neurogenesis and impairs spatial memory, but leaves overall health intact in rats (2021) Lensu, Sanna; et al.; A1; OA
- Most hippocampal CA1 pyramidal cells in rabbits increase firing during awake sharpwave ripples and some do so in response to external stimulation and theta (2020) Nokia, Miriam S.; et al.; A1; OA
- Breathe out and learn : Expiration-contingent stimulus presentation facilitates associative learning in trace eyeblink conditioning (2019) Waselius, Tomi; et al.; A1; OA
- Dentate spikes and learning : Disrupting hippocampal function during memory consolidation can improve pattern separation (2019) Lensu, Sanna; et al.; A1; OA
- Learning by heart : cardiac cycle reveals an effective time window for learning (2018) Waselius, Tomi; et al.; A1; OA
- Hippocampal electrical stimulation disrupts associative learning when targeted at dentate spikes (2017) Nokia, Miriam; et al.; A1; OA
- Hippocampal theta phase-contingent memory retrieval in delay and trace eyeblink conditioning (2017) Waselius, Tomi; et al.; A1; OA
