Gut microbes and metabolic disorders-
dissection of the underlying preventive and causal mechanisms and development of personalized dietary treatment strategies (GutMet)
Main funder
Funder's project number: 314212
Funds granted by main funder (€)
- 328 629,00
Funding program
Project timetable
Project start date: 01/09/2017
Project end date: 31/12/2020
Summary
Metabolic disorders (MDs) including non-alcoholic fatty liver disease (NAFLD) are major health problems. We will use commensal gut microbes to elucidate the mechanisms that affect host metabolic health both at organism and molecular level. This knowledge is needed to further understand the role of specific diets and therapeutic use of bacteria for prevention/treatment of MDs.
Specifically, we will confirm the disease-causing/preventive role of the specific gut microbes, elucidate the underlying pathologic mechanisms for the development of effective treatment strategies, combine data collected from human diets, gut microbiota composition, and in vitro studies to identify specific dietary compounds that affect the abundance of the harmful and beneficial microbes, to treat/prevent MDs in animal models and humans targeting the abundance harmful and beneficial microbes by specific diets.
Specifically, we will confirm the disease-causing/preventive role of the specific gut microbes, elucidate the underlying pathologic mechanisms for the development of effective treatment strategies, combine data collected from human diets, gut microbiota composition, and in vitro studies to identify specific dietary compounds that affect the abundance of the harmful and beneficial microbes, to treat/prevent MDs in animal models and humans targeting the abundance harmful and beneficial microbes by specific diets.
Principal Investigator
Primary responsible unit
Follow-up groups
Profiling area: Physical activity through life span (University of Jyväskylä JYU) PACTS
