Integrated OMICS and imaging for a better understanding of ecotoxicological mechanisms - PAH developmental toxicity as an example (research costs)


Main funder

Funder's project number: 319284


Funds granted by main funder (€)

  • 167 837,00


Funding program


Project timetable

Project start date: 01/09/2018

Project end date: 31/08/2020


Summary

Polynuclear aromatic hydrocarbons (PAHs) are ubiquitous contaminants in the environment, originating e.g. from petroleum products. Many of them cause developmental defects in vertebrates, embryonic fish being the most sensitive. The risk assessment of PAHs is currently oversimplified and based on wrong hypotheses of the mechanisms of toxicity and effects of mixtures. Therefore it underestimates the risk to developing fish.
This project studies the molecular mechanisms and the etiology of the developmental toxicity caused by PAHs in fish. The aim is to reveal the mechanisms by which different PAHs and their simple mixtures cause cardiovascular toxicity to developing fish. The results can be utilized in the environmental risk assessment of PAHs, making it more reliable.


Principal Investigator


Primary responsible unit


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Last updated on 2020-12-10 at 11:33