Integrated OMICS and imaging for a better understanding of ecotoxicological mechanisms - PAH developmental toxicity as an example (research costs)
Main funder
Funder's project number: 319284
Funds granted by main funder (€)
- 167 837,00
Funding program
Project timetable
Project start date: 01/09/2018
Project end date: 31/08/2020
Summary
Polynuclear aromatic hydrocarbons (PAHs) are ubiquitous contaminants in the environment, originating e.g. from petroleum products. Many of them cause developmental defects in vertebrates, embryonic fish being the most sensitive. The risk assessment of PAHs is currently oversimplified and based on wrong hypotheses of the mechanisms of toxicity and effects of mixtures. Therefore it underestimates the risk to developing fish.
This project studies the molecular mechanisms and the etiology of the developmental toxicity caused by PAHs in fish. The aim is to reveal the mechanisms by which different PAHs and their simple mixtures cause cardiovascular toxicity to developing fish. The results can be utilized in the environmental risk assessment of PAHs, making it more reliable.
This project studies the molecular mechanisms and the etiology of the developmental toxicity caused by PAHs in fish. The aim is to reveal the mechanisms by which different PAHs and their simple mixtures cause cardiovascular toxicity to developing fish. The results can be utilized in the environmental risk assessment of PAHs, making it more reliable.
Principal Investigator
Primary responsible unit
Related publications and other outputs
- Changes in cardiac proteome and metabolome following exposure to the PAHs retene and fluoranthene and their mixture in developing rainbow trout alevins (2022) Eriksson, Andreas N.M.; et al.; A1; OA
- Endogenous AhR agonist FICZ accumulates in rainbow trout (Oncorhynchus mykiss) alevins exposed to a mixture of two PAHs, retene and fluoranthene (2022) Eriksson, Andreas N. M.; et al.; A1; OA
- Exposure to retene, fluoranthene, and their binary mixture causes distinct transcriptomic and apical outcomes in rainbow trout (Oncorhynchus mykiss) yolk sac alevins (2022) Eriksson, Andreas N.M.; et al.; A1; OA
- Salmo trutta is more sensitive than Oncorhynchus mykiss to early-life stage exposure to retene (2022) Rigaud, Cyril; et al.; A1; OA
- Retene, pyrene and phenanthrene cause distinct molecular-level changes in the cardiac tissue of rainbow trout (Oncorhynchus mykiss) larvae, part 1 – Transcriptomics (2020) Rigaud, Cyril; et al.; A1; OA
- Retene, pyrene and phenanthrene cause distinct molecular-level changes in the cardiac tissue of rainbow trout (Oncorhynchus mykiss) larvae, Part 2 – Proteomics and metabolomics (2020) Rigaud, Cyril; et al.; A1; OA
- Polycyclic aromatic hydrocarbons phenanthrene and retene modify the action potential via multiple ion currents in rainbow trout Oncorhynchus mykiss cardiac myocytes (2019) Vehniäinen, Eeva-Riikka; et al.; A1; OA
